Culture-Free Enumeration of <i>Mycobacterium tuberculosis</i> in Mouse Tissues Using the Molecular Bacterial Load Assay for Preclinical Drug Development

Culture-Free Enumeration of <i>Mycobacterium tuberculosis</i> in Mouse Tissues Using the Molecular Bacterial Load Assay for Preclinical Drug Development

Background: The turnaround times for phenotypic tests used to monitor the bacterial load of <i>Mycobacterium tuberculosis</i>, in both clinical and preclinical studies, are delayed by the organism’s slow growth in culture media. The existence of differentially culturable populations of &...

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Bibliographic Details
Main Authors: Dimitrios Evangelopoulos, Carolyn M. Shoen, Isobella Honeyborne, Simon Clark, Ann Williams, Galina V. Mukamolova, Michael H. Cynamon, Timothy D. McHugh
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Microorganisms
Subjects:
culture-free quantification
16S ribosomal RNA
bacterial load
preclinical drug testing
drug combinations
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Online Access:https://www.mdpi.com/2076-2607/10/2/460

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