Lymphocyte to C-reactive protein ratio predicts long-term outcomes for patients with lower rectal cancer
Abstract Backgrounds The lymphocyte to C-reactive protein (CRP) ratio (LCR) is an indicator of systemic inflammation and host–tumor cell interactions. The aim of this study was to investigate the prognostic significance of LCR in lower rectal cancer patients who received preoperative chemo-radiother...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-07-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-021-02319-x |
| _version_ | 1818872260249780224 |
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| author | Masaaki Nishi Mistuo Shimada Takuya Tokunaga Jun Higashijima Kozo Yoshikawa Hideya Kashihara Chie Takasu Daichi Ishikawa Yuma Wada Shohei Eto Toshiaki Yoshimoto |
| author_facet | Masaaki Nishi Mistuo Shimada Takuya Tokunaga Jun Higashijima Kozo Yoshikawa Hideya Kashihara Chie Takasu Daichi Ishikawa Yuma Wada Shohei Eto Toshiaki Yoshimoto |
| author_sort | Masaaki Nishi |
| collection | DOAJ |
| description | Abstract Backgrounds The lymphocyte to C-reactive protein (CRP) ratio (LCR) is an indicator of systemic inflammation and host–tumor cell interactions. The aim of this study was to investigate the prognostic significance of LCR in lower rectal cancer patients who received preoperative chemo-radiotherapy (CRT). Methods Forty-eight patients with lower rectal cancer who underwent CRT followed by curative surgery were enrolled in this study. Routine blood examinations were performed before and after CRT were used to calculate pre-CRT LCR and post-CRT LCR. The median LCR was used to stratify patients into low and high LCR groups for analysis. The correlation between pre- and post-CRT LCR and clinical outcomes was retrospectively investigated. Results The pre-CRT LCR was significantly higher than the post-CRT LCR (11,765 and 6780, respectively, P < 0.05). The 5-year overall survival rate was significantly higher for patients with high post-CRT LCR compared with low post-CRT LCR (90.6% and 65.5%, respectively, P < 0.05). In univariate analysis, post-CRT LCR, post-CRT neutrophil to lymphocyte ratio, and fStage were significant prognostic factors for overall survival. In multivariate analysis, post-CRT LCR, but not other clinicopathological factors or prognostic indexes, was a significant prognostic factor for overall survival (P < 0.05). Conclusions Post-CRT LCR could be a prognostic biomarker for patients with lower rectal cancer. |
| first_indexed | 2024-12-19T12:35:59Z |
| format | Article |
| id | doaj.art-5fa6a92870614e08a7c6f1a51ca42870 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-19T12:35:59Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-5fa6a92870614e08a7c6f1a51ca428702022-12-21T20:21:09ZengBMCWorld Journal of Surgical Oncology1477-78192021-07-011911710.1186/s12957-021-02319-xLymphocyte to C-reactive protein ratio predicts long-term outcomes for patients with lower rectal cancerMasaaki Nishi0Mistuo Shimada1Takuya Tokunaga2Jun Higashijima3Kozo Yoshikawa4Hideya Kashihara5Chie Takasu6Daichi Ishikawa7Yuma Wada8Shohei Eto9Toshiaki Yoshimoto10Department of Surgery, Tokushima UniversityDepartment of Surgery, Tokushima UniversityDepartment of Surgery, Tokushima UniversityDepartment of Surgery, Tokushima UniversityDepartment of Surgery, Tokushima UniversityDepartment of Surgery, Tokushima UniversityDepartment of Surgery, Tokushima UniversityDepartment of Surgery, Tokushima UniversityDepartment of Surgery, Tokushima UniversityDepartment of Surgery, Tokushima UniversityDepartment of Surgery, Tokushima UniversityAbstract Backgrounds The lymphocyte to C-reactive protein (CRP) ratio (LCR) is an indicator of systemic inflammation and host–tumor cell interactions. The aim of this study was to investigate the prognostic significance of LCR in lower rectal cancer patients who received preoperative chemo-radiotherapy (CRT). Methods Forty-eight patients with lower rectal cancer who underwent CRT followed by curative surgery were enrolled in this study. Routine blood examinations were performed before and after CRT were used to calculate pre-CRT LCR and post-CRT LCR. The median LCR was used to stratify patients into low and high LCR groups for analysis. The correlation between pre- and post-CRT LCR and clinical outcomes was retrospectively investigated. Results The pre-CRT LCR was significantly higher than the post-CRT LCR (11,765 and 6780, respectively, P < 0.05). The 5-year overall survival rate was significantly higher for patients with high post-CRT LCR compared with low post-CRT LCR (90.6% and 65.5%, respectively, P < 0.05). In univariate analysis, post-CRT LCR, post-CRT neutrophil to lymphocyte ratio, and fStage were significant prognostic factors for overall survival. In multivariate analysis, post-CRT LCR, but not other clinicopathological factors or prognostic indexes, was a significant prognostic factor for overall survival (P < 0.05). Conclusions Post-CRT LCR could be a prognostic biomarker for patients with lower rectal cancer.https://doi.org/10.1186/s12957-021-02319-xRectal cancerChemoradiotherapyLymphocyte-CRP ratio |
| spellingShingle | Masaaki Nishi Mistuo Shimada Takuya Tokunaga Jun Higashijima Kozo Yoshikawa Hideya Kashihara Chie Takasu Daichi Ishikawa Yuma Wada Shohei Eto Toshiaki Yoshimoto Lymphocyte to C-reactive protein ratio predicts long-term outcomes for patients with lower rectal cancer World Journal of Surgical Oncology Rectal cancer Chemoradiotherapy Lymphocyte-CRP ratio |
| title | Lymphocyte to C-reactive protein ratio predicts long-term outcomes for patients with lower rectal cancer |
| title_full | Lymphocyte to C-reactive protein ratio predicts long-term outcomes for patients with lower rectal cancer |
| title_fullStr | Lymphocyte to C-reactive protein ratio predicts long-term outcomes for patients with lower rectal cancer |
| title_full_unstemmed | Lymphocyte to C-reactive protein ratio predicts long-term outcomes for patients with lower rectal cancer |
| title_short | Lymphocyte to C-reactive protein ratio predicts long-term outcomes for patients with lower rectal cancer |
| title_sort | lymphocyte to c reactive protein ratio predicts long term outcomes for patients with lower rectal cancer |
| topic | Rectal cancer Chemoradiotherapy Lymphocyte-CRP ratio |
| url | https://doi.org/10.1186/s12957-021-02319-x |
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