Defense peptides secreted by helminth pathogens: antimicrobial and/or immunomodulator molecules?
Host defense peptides (HDPs) are an evolutionarily conserved component of the innate immune response found in all living species. They possess antimicrobial activities against a broad range of organisms including bacteria, fungi, eukaryotic parasites and viruses. HDPs also have the ability to enhanc...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-08-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00269/full |
| _version_ | 1818931500040585216 |
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| author | Sophie eCotton Sheila eDonnelly Mark W. Robinson Mark W. Robinson John P. Dalton Karine eThivierge Karine eThivierge |
| author_facet | Sophie eCotton Sheila eDonnelly Mark W. Robinson Mark W. Robinson John P. Dalton Karine eThivierge Karine eThivierge |
| author_sort | Sophie eCotton |
| collection | DOAJ |
| description | Host defense peptides (HDPs) are an evolutionarily conserved component of the innate immune response found in all living species. They possess antimicrobial activities against a broad range of organisms including bacteria, fungi, eukaryotic parasites and viruses. HDPs also have the ability to enhance immune responses by acting as immunomodulators. We discovered a new family of HDPs derived from pathogenic helminthes (worms) that cause enormous disease in animals and humans worldwide. The discovery of these peptides was based on their similar biochemical and functional characteristics to the human defense peptide LL-37. We propose that these new peptides modulate the immune response via molecular mimicry of mammalian HDPs thus providing a mechanism behind the anti-inflammatory properties of helminth infections. |
| first_indexed | 2024-12-20T04:17:34Z |
| format | Article |
| id | doaj.art-5fa6aaf1e66b491fbe96d0cbe9c38903 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-20T04:17:34Z |
| publishDate | 2012-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-5fa6aaf1e66b491fbe96d0cbe9c389032022-12-21T19:53:44ZengFrontiers Media S.A.Frontiers in Immunology1664-32242012-08-01310.3389/fimmu.2012.0026931980Defense peptides secreted by helminth pathogens: antimicrobial and/or immunomodulator molecules?Sophie eCotton0Sheila eDonnelly1Mark W. Robinson2Mark W. Robinson3John P. Dalton4Karine eThivierge5Karine eThivierge6McGill UniversityUniversity of Technology Sydney (UTS)University of Technology Sydney (UTS)Queen's University BelfastMcGill UniversityMcGill UniversityInstitut national de santé publique du QuébecHost defense peptides (HDPs) are an evolutionarily conserved component of the innate immune response found in all living species. They possess antimicrobial activities against a broad range of organisms including bacteria, fungi, eukaryotic parasites and viruses. HDPs also have the ability to enhance immune responses by acting as immunomodulators. We discovered a new family of HDPs derived from pathogenic helminthes (worms) that cause enormous disease in animals and humans worldwide. The discovery of these peptides was based on their similar biochemical and functional characteristics to the human defense peptide LL-37. We propose that these new peptides modulate the immune response via molecular mimicry of mammalian HDPs thus providing a mechanism behind the anti-inflammatory properties of helminth infections.http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00269/fullHelminthsImmunomodulationParasitesInnate immune systemantimicrobial peptidesDefense peptides |
| spellingShingle | Sophie eCotton Sheila eDonnelly Mark W. Robinson Mark W. Robinson John P. Dalton Karine eThivierge Karine eThivierge Defense peptides secreted by helminth pathogens: antimicrobial and/or immunomodulator molecules? Frontiers in Immunology Helminths Immunomodulation Parasites Innate immune system antimicrobial peptides Defense peptides |
| title | Defense peptides secreted by helminth pathogens: antimicrobial and/or immunomodulator molecules? |
| title_full | Defense peptides secreted by helminth pathogens: antimicrobial and/or immunomodulator molecules? |
| title_fullStr | Defense peptides secreted by helminth pathogens: antimicrobial and/or immunomodulator molecules? |
| title_full_unstemmed | Defense peptides secreted by helminth pathogens: antimicrobial and/or immunomodulator molecules? |
| title_short | Defense peptides secreted by helminth pathogens: antimicrobial and/or immunomodulator molecules? |
| title_sort | defense peptides secreted by helminth pathogens antimicrobial and or immunomodulator molecules |
| topic | Helminths Immunomodulation Parasites Innate immune system antimicrobial peptides Defense peptides |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00269/full |
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