An Overview of NO Signaling Pathways in Aging
Nitric Oxide (NO) is a potent signaling molecule involved in the regulation of various cellular mechanisms and pathways under normal and pathological conditions. NO production, its effects, and its efficacy, are extremely sensitive to aging-related changes in the cells. Herein, we review the mechani...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/15/4533 |
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| author | Ali Mohammad Pourbagher-Shahri Tahereh Farkhondeh Marjan Talebi Dalia M. Kopustinskiene Saeed Samarghandian Jurga Bernatoniene |
| author_facet | Ali Mohammad Pourbagher-Shahri Tahereh Farkhondeh Marjan Talebi Dalia M. Kopustinskiene Saeed Samarghandian Jurga Bernatoniene |
| author_sort | Ali Mohammad Pourbagher-Shahri |
| collection | DOAJ |
| description | Nitric Oxide (NO) is a potent signaling molecule involved in the regulation of various cellular mechanisms and pathways under normal and pathological conditions. NO production, its effects, and its efficacy, are extremely sensitive to aging-related changes in the cells. Herein, we review the mechanisms of NO signaling in the cardiovascular system, central nervous system (CNS), reproduction system, as well as its effects on skin, kidneys, thyroid, muscles, and on the immune system during aging. The aging-related decline in NO levels and bioavailability is also discussed in this review. The decreased NO production by endothelial nitric oxide synthase (eNOS) was revealed in the aged cardiovascular system. In the CNS, the decline of the neuronal (n)NOS production of NO was related to the impairment of memory, sleep, and cognition. NO played an important role in the aging of oocytes and aged-induced erectile dysfunction. Aging downregulated NO signaling pathways in endothelial cells resulting in skin, kidney, thyroid, and muscle disorders. Putative therapeutic agents (natural/synthetic) affecting NO signaling mechanisms in the aging process are discussed in the present study. In summary, all of the studies reviewed demonstrate that NO plays a crucial role in the cellular aging processes. |
| first_indexed | 2024-03-10T09:11:05Z |
| format | Article |
| id | doaj.art-5fa7ee6606f249368a49d97b9e614287 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T09:11:05Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5fa7ee6606f249368a49d97b9e6142872023-11-22T05:59:30ZengMDPI AGMolecules1420-30492021-07-012615453310.3390/molecules26154533An Overview of NO Signaling Pathways in AgingAli Mohammad Pourbagher-Shahri0Tahereh Farkhondeh1Marjan Talebi2Dalia M. Kopustinskiene3Saeed Samarghandian4Jurga Bernatoniene5Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand 9717853577, IranCardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand 9717853577, IranDepartment of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran 1991953381, IranInstitute of Pharmaceutical Technologies, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Sukileliu Pr. 13, LT-50161 Kaunas, LithuaniaNoncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur 9318614139, IranInstitute of Pharmaceutical Technologies, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Sukileliu Pr. 13, LT-50161 Kaunas, LithuaniaNitric Oxide (NO) is a potent signaling molecule involved in the regulation of various cellular mechanisms and pathways under normal and pathological conditions. NO production, its effects, and its efficacy, are extremely sensitive to aging-related changes in the cells. Herein, we review the mechanisms of NO signaling in the cardiovascular system, central nervous system (CNS), reproduction system, as well as its effects on skin, kidneys, thyroid, muscles, and on the immune system during aging. The aging-related decline in NO levels and bioavailability is also discussed in this review. The decreased NO production by endothelial nitric oxide synthase (eNOS) was revealed in the aged cardiovascular system. In the CNS, the decline of the neuronal (n)NOS production of NO was related to the impairment of memory, sleep, and cognition. NO played an important role in the aging of oocytes and aged-induced erectile dysfunction. Aging downregulated NO signaling pathways in endothelial cells resulting in skin, kidney, thyroid, and muscle disorders. Putative therapeutic agents (natural/synthetic) affecting NO signaling mechanisms in the aging process are discussed in the present study. In summary, all of the studies reviewed demonstrate that NO plays a crucial role in the cellular aging processes.https://www.mdpi.com/1420-3049/26/15/4533nitric oxidenitric oxide synthaseagingsenescenceNO signaling pathwaystherapeutic agents |
| spellingShingle | Ali Mohammad Pourbagher-Shahri Tahereh Farkhondeh Marjan Talebi Dalia M. Kopustinskiene Saeed Samarghandian Jurga Bernatoniene An Overview of NO Signaling Pathways in Aging Molecules nitric oxide nitric oxide synthase aging senescence NO signaling pathways therapeutic agents |
| title | An Overview of NO Signaling Pathways in Aging |
| title_full | An Overview of NO Signaling Pathways in Aging |
| title_fullStr | An Overview of NO Signaling Pathways in Aging |
| title_full_unstemmed | An Overview of NO Signaling Pathways in Aging |
| title_short | An Overview of NO Signaling Pathways in Aging |
| title_sort | overview of no signaling pathways in aging |
| topic | nitric oxide nitric oxide synthase aging senescence NO signaling pathways therapeutic agents |
| url | https://www.mdpi.com/1420-3049/26/15/4533 |
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