A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery
The mechanisms underlying mitochondrial quality control are not fully understood. Here the authors identify a switch from degradative to secretory autophagy in the absence of the mATG8-conjugation system, termed Autophagic Secretion of Mitochondria.
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-06-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31213-7 |
| _version_ | 1828336739723247616 |
|---|---|
| author | Hayden Weng Siong Tan Guang Lu Han Dong Yik-Lam Cho Auginia Natalia Liming Wang Charlene Chan Dennis Kappei Reshma Taneja Shuo-Chien Ling Huilin Shao Shih-Yin Tsai Wen-Xing Ding Han-Ming Shen |
| author_facet | Hayden Weng Siong Tan Guang Lu Han Dong Yik-Lam Cho Auginia Natalia Liming Wang Charlene Chan Dennis Kappei Reshma Taneja Shuo-Chien Ling Huilin Shao Shih-Yin Tsai Wen-Xing Ding Han-Ming Shen |
| author_sort | Hayden Weng Siong Tan |
| collection | DOAJ |
| description | The mechanisms underlying mitochondrial quality control are not fully understood. Here the authors identify a switch from degradative to secretory autophagy in the absence of the mATG8-conjugation system, termed Autophagic Secretion of Mitochondria. |
| first_indexed | 2024-04-13T22:05:07Z |
| format | Article |
| id | doaj.art-5faa98dd54e74eb38a71aec60636557b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T22:05:07Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-5faa98dd54e74eb38a71aec60636557b2022-12-22T02:27:58ZengNature PortfolioNature Communications2041-17232022-06-0113111710.1038/s41467-022-31213-7A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machineryHayden Weng Siong Tan0Guang Lu1Han Dong2Yik-Lam Cho3Auginia Natalia4Liming Wang5Charlene Chan6Dennis Kappei7Reshma Taneja8Shuo-Chien Ling9Huilin Shao10Shih-Yin Tsai11Wen-Xing Ding12Han-Ming Shen13Department of Physiology, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Physiology, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Physiology, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Physiology, Yong Loo Lin School of Medicine, National University of SingaporeInstitute for Health Innovation & Technology, National University of SingaporeDepartment of Physiology, Yong Loo Lin School of Medicine, National University of SingaporeCancer Science Institute of Singapore, National University of SingaporeCancer Science Institute of Singapore, National University of SingaporeDepartment of Physiology, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Physiology, Yong Loo Lin School of Medicine, National University of SingaporeInstitute for Health Innovation & Technology, National University of SingaporeDepartment of Physiology, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical CenterDepartment of Physiology, Yong Loo Lin School of Medicine, National University of SingaporeThe mechanisms underlying mitochondrial quality control are not fully understood. Here the authors identify a switch from degradative to secretory autophagy in the absence of the mATG8-conjugation system, termed Autophagic Secretion of Mitochondria.https://doi.org/10.1038/s41467-022-31213-7 |
| spellingShingle | Hayden Weng Siong Tan Guang Lu Han Dong Yik-Lam Cho Auginia Natalia Liming Wang Charlene Chan Dennis Kappei Reshma Taneja Shuo-Chien Ling Huilin Shao Shih-Yin Tsai Wen-Xing Ding Han-Ming Shen A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery Nature Communications |
| title | A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery |
| title_full | A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery |
| title_fullStr | A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery |
| title_full_unstemmed | A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery |
| title_short | A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery |
| title_sort | degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the matg8 conjugation machinery |
| url | https://doi.org/10.1038/s41467-022-31213-7 |
| work_keys_str_mv | AT haydenwengsiongtan adegradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery AT guanglu adegradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery AT handong adegradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery AT yiklamcho adegradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery AT auginianatalia adegradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery AT limingwang adegradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery AT charlenechan adegradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery AT denniskappei adegradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery AT reshmataneja adegradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery AT shuochienling adegradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery AT huilinshao adegradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery AT shihyintsai adegradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery AT wenxingding adegradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery AT hanmingshen adegradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery AT haydenwengsiongtan degradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery AT guanglu degradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery AT handong degradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery AT yiklamcho degradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery AT auginianatalia degradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery AT limingwang degradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery AT charlenechan degradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery AT denniskappei degradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery AT reshmataneja degradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery AT shuochienling degradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery AT huilinshao degradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery AT shihyintsai degradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery AT wenxingding degradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery AT hanmingshen degradativetosecretoryautophagyswitchmediatesmitochondriaclearanceintheabsenceofthematg8conjugationmachinery |