Co-expression of t(15;17) and t(8;21) in a Case of Acute Promyelocytic Leukemia: Review of the Literature
Additional chromosomal abnormalities in acute myelogenous leukemia have been identified as one of the most important prognostic factors. Favorable chromosomal changes such as t(8;21), inv(16), and t(15;17) are associated with higher rates of complete remission and event-free survival. Translocation...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2013-12-01
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| Series: | Turkish Journal of Hematology |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-81488 |
| _version_ | 1797909026138226688 |
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| author | Burak Uz Eylem Eliaçık Ayse Işık Salih Aksu Yahya Büyükaşık İbrahim C. Haznedaroğlu Hakan Göker Nilgün Sayınalp Osman İ. Özcebe |
| author_facet | Burak Uz Eylem Eliaçık Ayse Işık Salih Aksu Yahya Büyükaşık İbrahim C. Haznedaroğlu Hakan Göker Nilgün Sayınalp Osman İ. Özcebe |
| author_sort | Burak Uz |
| collection | DOAJ |
| description | Additional chromosomal abnormalities in acute myelogenous leukemia have been identified as one of the most important prognostic factors. Favorable chromosomal changes such as t(8;21), inv(16), and t(15;17) are associated with higher rates of complete remission and event-free survival. Translocation (15;17) characterizes acute promyelocytic leukemia (APL) (French- American-British class M3) in almost all patients. Secondary chromosomal abnormalities are also present in approximately 23%-29% of patients with newly diagnosed APL. The prognostic implications of t(8;21) and other secondary cytogenetic aberrations in APL are reviewed here. We present a 47-year-old woman diagnosed with APL whose initial cytogenetic analysis included both t(8;21) and t(15;17). The initial induction chemotherapy included 3 days of idarubicin (12 mg/m2/day) and daily all-trans retinoic acid (ATRA; 45 mg/m2/day). At the sixth week of treatment, a control bone marrow biopsy was found to be normocellular, t(15;17) bcr3 and t(8;21) were negative, and t(15;17) bcr1 fusion transcripts were reduced from 5007 (1.78525699%) copies per 1 μg RNA to 40 (0.00062020%) with real-time quantitative polymerase chain reaction. Consolidation with 4 days of idarubicin (5 mg/m2/day), ATRA (45 mg/m2/day for 15 days), and cytarabine (1 g/m2/day for 4 days) was then started. However, the patient became pancytopenic and had neutropenic fever after consolidation treatment. Unfortunately, she died 3 months after the time of APL diagnosis, due to acute respiratory distress syndrome-like respiratory problems and multiorgan dysfunction requiring respiratory support and hemodialysis. |
| first_indexed | 2024-04-10T11:03:03Z |
| format | Article |
| id | doaj.art-5fabb871b9d149a28d5e05e908a6ed46 |
| institution | Directory Open Access Journal |
| issn | 1308-5263 |
| language | English |
| last_indexed | 2024-04-10T11:03:03Z |
| publishDate | 2013-12-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Hematology |
| spelling | doaj.art-5fabb871b9d149a28d5e05e908a6ed462023-02-15T16:19:35ZengGalenos Publishing HouseTurkish Journal of Hematology1308-52632013-12-0130440040410.4274/Tjh.2012.0180TJH-81488Co-expression of t(15;17) and t(8;21) in a Case of Acute Promyelocytic Leukemia: Review of the LiteratureBurak Uz0Eylem Eliaçık1Ayse Işık2Salih Aksu3Yahya Büyükaşık4İbrahim C. Haznedaroğlu5Hakan Göker6Nilgün Sayınalp7Osman İ. Özcebe8Hacettepe University Medical School, Department Of Internal Medicine, Division Of Hematology, Ankara, TurkeyHacettepe University Medical School, Department Of Internal Medicine, Division Of Hematology, Ankara, TurkeyHacettepe University Medical School, Department Of Internal Medicine, Division Of Hematology, Ankara, TurkeyHacettepe University Medical School, Department Of Internal Medicine, Division Of Hematology, Ankara, TurkeyHacettepe University Medical School, Department Of Internal Medicine, Division Of Hematology, Ankara, TurkeyHacettepe University Medical School, Department Of Internal Medicine, Division Of Hematology, Ankara, TurkeyHacettepe University Medical School, Department Of Internal Medicine, Division Of Hematology, Ankara, TurkeyHacettepe University Medical School, Department Of Internal Medicine, Division Of Hematology, Ankara, TurkeyHacettepe University Medical School, Department Of Internal Medicine, Division Of Hematology, Ankara, TurkeyAdditional chromosomal abnormalities in acute myelogenous leukemia have been identified as one of the most important prognostic factors. Favorable chromosomal changes such as t(8;21), inv(16), and t(15;17) are associated with higher rates of complete remission and event-free survival. Translocation (15;17) characterizes acute promyelocytic leukemia (APL) (French- American-British class M3) in almost all patients. Secondary chromosomal abnormalities are also present in approximately 23%-29% of patients with newly diagnosed APL. The prognostic implications of t(8;21) and other secondary cytogenetic aberrations in APL are reviewed here. We present a 47-year-old woman diagnosed with APL whose initial cytogenetic analysis included both t(8;21) and t(15;17). The initial induction chemotherapy included 3 days of idarubicin (12 mg/m2/day) and daily all-trans retinoic acid (ATRA; 45 mg/m2/day). At the sixth week of treatment, a control bone marrow biopsy was found to be normocellular, t(15;17) bcr3 and t(8;21) were negative, and t(15;17) bcr1 fusion transcripts were reduced from 5007 (1.78525699%) copies per 1 μg RNA to 40 (0.00062020%) with real-time quantitative polymerase chain reaction. Consolidation with 4 days of idarubicin (5 mg/m2/day), ATRA (45 mg/m2/day for 15 days), and cytarabine (1 g/m2/day for 4 days) was then started. However, the patient became pancytopenic and had neutropenic fever after consolidation treatment. Unfortunately, she died 3 months after the time of APL diagnosis, due to acute respiratory distress syndrome-like respiratory problems and multiorgan dysfunction requiring respiratory support and hemodialysis.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-81488additional chromosomal abnormalitiesacute promyelocytic leukemia |
| spellingShingle | Burak Uz Eylem Eliaçık Ayse Işık Salih Aksu Yahya Büyükaşık İbrahim C. Haznedaroğlu Hakan Göker Nilgün Sayınalp Osman İ. Özcebe Co-expression of t(15;17) and t(8;21) in a Case of Acute Promyelocytic Leukemia: Review of the Literature Turkish Journal of Hematology additional chromosomal abnormalities acute promyelocytic leukemia |
| title | Co-expression of t(15;17) and t(8;21) in a Case of Acute Promyelocytic Leukemia: Review of the Literature |
| title_full | Co-expression of t(15;17) and t(8;21) in a Case of Acute Promyelocytic Leukemia: Review of the Literature |
| title_fullStr | Co-expression of t(15;17) and t(8;21) in a Case of Acute Promyelocytic Leukemia: Review of the Literature |
| title_full_unstemmed | Co-expression of t(15;17) and t(8;21) in a Case of Acute Promyelocytic Leukemia: Review of the Literature |
| title_short | Co-expression of t(15;17) and t(8;21) in a Case of Acute Promyelocytic Leukemia: Review of the Literature |
| title_sort | co expression of t 15 17 and t 8 21 in a case of acute promyelocytic leukemia review of the literature |
| topic | additional chromosomal abnormalities acute promyelocytic leukemia |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-81488 |
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