Are interstitial lung abnormalities associated with COPD? A nested case–control study
Francesca Bozzetti,1 Ilaria Paladini,1 Enrico Rabaiotti,2 Alessandro Franceschini,1 Veronica Alfieri,3 Alfredo Chetta,3 Ernesto Crisafulli,3 Mario Silva,2 Ugo Pastorino,4 Nicola Sverzellati11Section of Radiology, Department of Surgical Sciences, University of Parma, 2Department of Radiology, Academi...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2016-05-01
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| Series: | International Journal of COPD |
| Subjects: | |
| Online Access: | https://www.dovepress.com/are-interstitial-lung-abnormalities-associated-with-copd-a-nested-case-peer-reviewed-article-COPD |
| _version_ | 1818981098004152320 |
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| author | Bozzetti F Paladini I Rabaiotti E Franceschini A Alfieri V Chetta A Crisafulli E Silva M Pastorino U Sverzellati N |
| author_facet | Bozzetti F Paladini I Rabaiotti E Franceschini A Alfieri V Chetta A Crisafulli E Silva M Pastorino U Sverzellati N |
| author_sort | Bozzetti F |
| collection | DOAJ |
| description | Francesca Bozzetti,1 Ilaria Paladini,1 Enrico Rabaiotti,2 Alessandro Franceschini,1 Veronica Alfieri,3 Alfredo Chetta,3 Ernesto Crisafulli,3 Mario Silva,2 Ugo Pastorino,4 Nicola Sverzellati11Section of Radiology, Department of Surgical Sciences, University of Parma, 2Department of Radiology, Academic Hospital of Parma, 3Respiratory Disease and Lung Function Unit, Department of Clinical and Experimental Medicine, University of Parma, Parma, 4Division of Thoracic Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, ItalyPurpose: In this study, we tested the association between COPD and interstitial lung abnormality (ILA), notably in relation to the presence of computed tomography (CT) signs of lung fibrosis.Patients and methods: COPD cases were selected from participants undergoing lung cancer screening (Multicentric Italian Lung Detection trial) for airflow obstruction (n=311/2,303, 13.5%) and 146 consecutive patients with clinical COPD. In all, 457 COPD cases were selected and classified according to the stages of Global Initiative for Chronic Obstructive Lung Disease. A nested matching (case:control =1:2) according to age, sex, and smoking history was operated between each COPD case and two control subjects from Multicentric Italian Lung Detection trial without airflow obstruction. Low-dose CT scans of COPD cases and controls were reviewed for the presence of ILA, which were classified into definite or indeterminate according to the presence of signs of lung fibrosis.Results: The frequency of definite ILA was similar between COPD cases and controls (P=0.2), independent of the presence of signs of lung fibrosis (P=0.07). Combined definite and indeterminate ILA was homogeneously distributed across Global Initiative for Chronic Obstructive Lung Disease stages (P=0.6). Definite ILA was directly associated with current smoker status (odds ratio [OR] 4.05, 95% confidence interval [CI]: 2.2–7.4) and increasing pack-years (OR 1.01, 95% CI: 1–1.02). Subjects with any fibrotic ILA were more likely to be older (OR 1.17, 95% CI: 1.10–1.25) and male (OR 8.58, 95% CI: 1.58–68.9).Conclusion: There was no association between COPD and definite ILA. However, low-dose CT signs of lung fibrosis were also observed in COPD, and their clinical relevance is yet to be determined.Keywords: interstitial lung abnormality, chronic obstructive lung disease, usual interstitial pneumonia, airspace enlargement with fibrosis |
| first_indexed | 2024-12-20T17:25:55Z |
| format | Article |
| id | doaj.art-5fabdcb411b84d65b662681c8a53c58d |
| institution | Directory Open Access Journal |
| issn | 1178-2005 |
| language | English |
| last_indexed | 2024-12-20T17:25:55Z |
| publishDate | 2016-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of COPD |
| spelling | doaj.art-5fabdcb411b84d65b662681c8a53c58d2022-12-21T19:31:36ZengDove Medical PressInternational Journal of COPD1178-20052016-05-012016Issue 11087109627140Are interstitial lung abnormalities associated with COPD? A nested case–control studyBozzetti FPaladini IRabaiotti EFranceschini AAlfieri VChetta ACrisafulli ESilva MPastorino USverzellati NFrancesca Bozzetti,1 Ilaria Paladini,1 Enrico Rabaiotti,2 Alessandro Franceschini,1 Veronica Alfieri,3 Alfredo Chetta,3 Ernesto Crisafulli,3 Mario Silva,2 Ugo Pastorino,4 Nicola Sverzellati11Section of Radiology, Department of Surgical Sciences, University of Parma, 2Department of Radiology, Academic Hospital of Parma, 3Respiratory Disease and Lung Function Unit, Department of Clinical and Experimental Medicine, University of Parma, Parma, 4Division of Thoracic Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, ItalyPurpose: In this study, we tested the association between COPD and interstitial lung abnormality (ILA), notably in relation to the presence of computed tomography (CT) signs of lung fibrosis.Patients and methods: COPD cases were selected from participants undergoing lung cancer screening (Multicentric Italian Lung Detection trial) for airflow obstruction (n=311/2,303, 13.5%) and 146 consecutive patients with clinical COPD. In all, 457 COPD cases were selected and classified according to the stages of Global Initiative for Chronic Obstructive Lung Disease. A nested matching (case:control =1:2) according to age, sex, and smoking history was operated between each COPD case and two control subjects from Multicentric Italian Lung Detection trial without airflow obstruction. Low-dose CT scans of COPD cases and controls were reviewed for the presence of ILA, which were classified into definite or indeterminate according to the presence of signs of lung fibrosis.Results: The frequency of definite ILA was similar between COPD cases and controls (P=0.2), independent of the presence of signs of lung fibrosis (P=0.07). Combined definite and indeterminate ILA was homogeneously distributed across Global Initiative for Chronic Obstructive Lung Disease stages (P=0.6). Definite ILA was directly associated with current smoker status (odds ratio [OR] 4.05, 95% confidence interval [CI]: 2.2–7.4) and increasing pack-years (OR 1.01, 95% CI: 1–1.02). Subjects with any fibrotic ILA were more likely to be older (OR 1.17, 95% CI: 1.10–1.25) and male (OR 8.58, 95% CI: 1.58–68.9).Conclusion: There was no association between COPD and definite ILA. However, low-dose CT signs of lung fibrosis were also observed in COPD, and their clinical relevance is yet to be determined.Keywords: interstitial lung abnormality, chronic obstructive lung disease, usual interstitial pneumonia, airspace enlargement with fibrosishttps://www.dovepress.com/are-interstitial-lung-abnormalities-associated-with-copd-a-nested-case-peer-reviewed-article-COPDinterstitial lung abnormalitychronic obstructive lung diseaseusual interstitial pneumoniaairspace enlargement with fibrosis |
| spellingShingle | Bozzetti F Paladini I Rabaiotti E Franceschini A Alfieri V Chetta A Crisafulli E Silva M Pastorino U Sverzellati N Are interstitial lung abnormalities associated with COPD? A nested case–control study International Journal of COPD interstitial lung abnormality chronic obstructive lung disease usual interstitial pneumonia airspace enlargement with fibrosis |
| title | Are interstitial lung abnormalities associated with COPD? A nested case–control study |
| title_full | Are interstitial lung abnormalities associated with COPD? A nested case–control study |
| title_fullStr | Are interstitial lung abnormalities associated with COPD? A nested case–control study |
| title_full_unstemmed | Are interstitial lung abnormalities associated with COPD? A nested case–control study |
| title_short | Are interstitial lung abnormalities associated with COPD? A nested case–control study |
| title_sort | are interstitial lung abnormalities associated with copd a nested case ndash control study |
| topic | interstitial lung abnormality chronic obstructive lung disease usual interstitial pneumonia airspace enlargement with fibrosis |
| url | https://www.dovepress.com/are-interstitial-lung-abnormalities-associated-with-copd-a-nested-case-peer-reviewed-article-COPD |
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