Identification and Clinical Characteristics of Community-Acquired <i>Acinetobacter baumannii</i> in Patients Hospitalized for Moderate or Severe COVID-19 in Peru
<i>Acinetobacter baumannii</i> has been described as a cause of serious community-acquired infections in tropical countries. Currently, its implications when simultaneously identified with other pathogens are not yet adequately understood. A descriptive study was conducted on hospitalize...
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| Format: | Article |
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MDPI AG
2024-03-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/13/3/266 |
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| author | Wilmer Silva-Caso Giancarlo Pérez-Lazo Miguel Angel Aguilar-Luis Adriana Morales-Moreno José Ballena-López Fernando Soto-Febres Johanna Martins-Luna Luis J. Del Valle Sungmin Kym Deysi Aguilar-Luis Dayana Denegri-Hinostroza Juana del Valle-Mendoza |
| author_facet | Wilmer Silva-Caso Giancarlo Pérez-Lazo Miguel Angel Aguilar-Luis Adriana Morales-Moreno José Ballena-López Fernando Soto-Febres Johanna Martins-Luna Luis J. Del Valle Sungmin Kym Deysi Aguilar-Luis Dayana Denegri-Hinostroza Juana del Valle-Mendoza |
| author_sort | Wilmer Silva-Caso |
| collection | DOAJ |
| description | <i>Acinetobacter baumannii</i> has been described as a cause of serious community-acquired infections in tropical countries. Currently, its implications when simultaneously identified with other pathogens are not yet adequately understood. A descriptive study was conducted on hospitalized patients with a diagnosis of moderate/severe SARS-CoV-2-induced pneumonia confirmed via real-time RT-PCR. Patients aged > 18 years who were admitted to a specialized COVID-19 treatment center in Peru were selected for enrollment. <i>A. baumannii</i> was detected via the PCR amplification of the <i>bla</i><sub>OXA-51</sub> gene obtained from nasopharyngeal swabs within 48 h of hospitalization. A total of 295 patients with COVID-19 who met the study inclusion criteria were enrolled. <i>A. baumannii</i> was simultaneously identified in 40/295 (13.5%) of COVID-19-hospitalized patients. Demographic data and comorbidities were comparable in both <i>Acinetobacter</i>-positive and -negative subgroups. However, patients identified as being infected with <i>Acinetobacter</i> were more likely to have received outpatient antibiotics prior to hospitalization, had a higher requirement for high-flow nasal cannula and a higher subjective incidence of fatigue, and were more likely to develop <i>Acinetobacter</i>-induced pneumonia during hospitalization. Conclusions: The group in which SARS-CoV-2 and <i>A. baumannii</i> were simultaneously identified had a higher proportion of fatigue, a higher frequency of requiring a high-flow cannula, and a higher proportion of superinfection with the same microorganism during hospitalization. |
| first_indexed | 2024-04-24T18:36:39Z |
| format | Article |
| id | doaj.art-5faca58fb8504d96a933440a94744f74 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-04-24T18:36:39Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-5faca58fb8504d96a933440a94744f742024-03-27T13:18:14ZengMDPI AGAntibiotics2079-63822024-03-0113326610.3390/antibiotics13030266Identification and Clinical Characteristics of Community-Acquired <i>Acinetobacter baumannii</i> in Patients Hospitalized for Moderate or Severe COVID-19 in PeruWilmer Silva-Caso0Giancarlo Pérez-Lazo1Miguel Angel Aguilar-Luis2Adriana Morales-Moreno3José Ballena-López4Fernando Soto-Febres5Johanna Martins-Luna6Luis J. Del Valle7Sungmin Kym8Deysi Aguilar-Luis9Dayana Denegri-Hinostroza10Juana del Valle-Mendoza11School of Medicine, Research Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima 15023, PeruDivision of Infectious Diseases, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima 15033, PeruSchool of Medicine, Research Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima 15023, PeruDivision of Infectious Diseases, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima 15033, PeruDivision of Infectious Diseases, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima 15033, PeruDivision of Infectious Diseases, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima 15033, PeruSchool of Medicine, Research Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima 15023, PeruBarcelona Research Center for Multiscale Science and Engineering, Departament d’Enginyeria Química, EEBE, Universitat Politècnica de Catalunya (UPC), 08034 Barcelona, SpainKorea International Cooperation for Infectious Diseases, College of Medicine, Chungnam National University, Daejeon 35015, Republic of KoreaSchool of Medicine, Research Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima 15023, PeruSchool of Medicine, Research Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima 15023, PeruSchool of Medicine, Research Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru<i>Acinetobacter baumannii</i> has been described as a cause of serious community-acquired infections in tropical countries. Currently, its implications when simultaneously identified with other pathogens are not yet adequately understood. A descriptive study was conducted on hospitalized patients with a diagnosis of moderate/severe SARS-CoV-2-induced pneumonia confirmed via real-time RT-PCR. Patients aged > 18 years who were admitted to a specialized COVID-19 treatment center in Peru were selected for enrollment. <i>A. baumannii</i> was detected via the PCR amplification of the <i>bla</i><sub>OXA-51</sub> gene obtained from nasopharyngeal swabs within 48 h of hospitalization. A total of 295 patients with COVID-19 who met the study inclusion criteria were enrolled. <i>A. baumannii</i> was simultaneously identified in 40/295 (13.5%) of COVID-19-hospitalized patients. Demographic data and comorbidities were comparable in both <i>Acinetobacter</i>-positive and -negative subgroups. However, patients identified as being infected with <i>Acinetobacter</i> were more likely to have received outpatient antibiotics prior to hospitalization, had a higher requirement for high-flow nasal cannula and a higher subjective incidence of fatigue, and were more likely to develop <i>Acinetobacter</i>-induced pneumonia during hospitalization. Conclusions: The group in which SARS-CoV-2 and <i>A. baumannii</i> were simultaneously identified had a higher proportion of fatigue, a higher frequency of requiring a high-flow cannula, and a higher proportion of superinfection with the same microorganism during hospitalization.https://www.mdpi.com/2079-6382/13/3/266community-acquired infections<i>Acinetobacter baumannii</i>OXA-51 gene |
| spellingShingle | Wilmer Silva-Caso Giancarlo Pérez-Lazo Miguel Angel Aguilar-Luis Adriana Morales-Moreno José Ballena-López Fernando Soto-Febres Johanna Martins-Luna Luis J. Del Valle Sungmin Kym Deysi Aguilar-Luis Dayana Denegri-Hinostroza Juana del Valle-Mendoza Identification and Clinical Characteristics of Community-Acquired <i>Acinetobacter baumannii</i> in Patients Hospitalized for Moderate or Severe COVID-19 in Peru Antibiotics community-acquired infections <i>Acinetobacter baumannii</i> OXA-51 gene |
| title | Identification and Clinical Characteristics of Community-Acquired <i>Acinetobacter baumannii</i> in Patients Hospitalized for Moderate or Severe COVID-19 in Peru |
| title_full | Identification and Clinical Characteristics of Community-Acquired <i>Acinetobacter baumannii</i> in Patients Hospitalized for Moderate or Severe COVID-19 in Peru |
| title_fullStr | Identification and Clinical Characteristics of Community-Acquired <i>Acinetobacter baumannii</i> in Patients Hospitalized for Moderate or Severe COVID-19 in Peru |
| title_full_unstemmed | Identification and Clinical Characteristics of Community-Acquired <i>Acinetobacter baumannii</i> in Patients Hospitalized for Moderate or Severe COVID-19 in Peru |
| title_short | Identification and Clinical Characteristics of Community-Acquired <i>Acinetobacter baumannii</i> in Patients Hospitalized for Moderate or Severe COVID-19 in Peru |
| title_sort | identification and clinical characteristics of community acquired i acinetobacter baumannii i in patients hospitalized for moderate or severe covid 19 in peru |
| topic | community-acquired infections <i>Acinetobacter baumannii</i> OXA-51 gene |
| url | https://www.mdpi.com/2079-6382/13/3/266 |
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