Carbamazepine Induces Platelet Apoptosis and Thrombocytopenia Through Protein Kinase A

Carbamazepine Induces Platelet Apoptosis and Thrombocytopenia Through Protein Kinase A

Carbamazepine is extensively used worldwide to treat a wide range of disorders such as epilepsy, peripheral neuralgia and bipolar disorder. Thrombocytopenia and hemorrhage have been identified in multiple carbamazepine-treated patients. However, the underlying mechanism remains poorly understood. He...

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Bibliographic Details
Main Authors: Weiling Xiao, Kangxi Zhou, Mengnan Yang, Chenglin Sun, Lan Dai, Jian Gu, Rong Yan, Kesheng Dai
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
carbamazepine
thrombocytopenia
PKA
platelet apoptosis
PDE3A
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.749930/full

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