Identification of both GABAA receptors and voltage-activated Na+ channels as molecular targets of anticonvulsant α-asarone

Identification of both GABAA receptors and voltage-activated Na+ channels as molecular targets of anticonvulsant α-asarone

Alpha (α)-asarone, a major effective component isolated from the Chinese medicinal herb Acorus tatarinowii, is clinically used as medication for treating epilepsy, cough, bronchitis, and asthma. In the present study, we demonstrated that α-asarone targets central nervous system GABAA receptor as we...

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Bibliographic Details
Main Authors: Ze-Jun eWang, Simmon Rock Levinson, Liqin eSun, Thomas eHeinbockel
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-03-01
Series:Frontiers in Pharmacology
Subjects:
Olfactory Bulb
Sodium Channel Blockers
Sodium Channels
GABAA receptors
anticonvulsant
α-asarone
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00040/full

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