Emergence of assortative mixing between clusters of cultured neurons.
The analysis of the activity of neuronal cultures is considered to be a good proxy of the functional connectivity of in vivo neuronal tissues. Thus, the functional complex network inferred from activity patterns is a promising way to unravel the interplay between structure and functionality of neuro...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-09-01
|
| Series: | PLoS Computational Biology |
| Online Access: | http://europepmc.org/articles/PMC4154651?pdf=render |
| _version_ | 1818142464882507776 |
|---|---|
| author | Sara Teller Clara Granell Manlio De Domenico Jordi Soriano Sergio Gómez Alex Arenas |
| author_facet | Sara Teller Clara Granell Manlio De Domenico Jordi Soriano Sergio Gómez Alex Arenas |
| author_sort | Sara Teller |
| collection | DOAJ |
| description | The analysis of the activity of neuronal cultures is considered to be a good proxy of the functional connectivity of in vivo neuronal tissues. Thus, the functional complex network inferred from activity patterns is a promising way to unravel the interplay between structure and functionality of neuronal systems. Here, we monitor the spontaneous self-sustained dynamics in neuronal cultures formed by interconnected aggregates of neurons (clusters). Dynamics is characterized by the fast activation of groups of clusters in sequences termed bursts. The analysis of the time delays between clusters' activations within the bursts allows the reconstruction of the directed functional connectivity of the network. We propose a method to statistically infer this connectivity and analyze the resulting properties of the associated complex networks. Surprisingly enough, in contrast to what has been reported for many biological networks, the clustered neuronal cultures present assortative mixing connectivity values, meaning that there is a preference for clusters to link to other clusters that share similar functional connectivity, as well as a rich-club core, which shapes a 'connectivity backbone' in the network. These results point out that the grouping of neurons and the assortative connectivity between clusters are intrinsic survival mechanisms of the culture. |
| first_indexed | 2024-12-11T11:16:12Z |
| format | Article |
| id | doaj.art-5fb31612db434ddca8e65e81eb8e2b83 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-12-11T11:16:12Z |
| publishDate | 2014-09-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-5fb31612db434ddca8e65e81eb8e2b832022-12-22T01:09:19ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582014-09-01109e100379610.1371/journal.pcbi.1003796Emergence of assortative mixing between clusters of cultured neurons.Sara TellerClara GranellManlio De DomenicoJordi SorianoSergio GómezAlex ArenasThe analysis of the activity of neuronal cultures is considered to be a good proxy of the functional connectivity of in vivo neuronal tissues. Thus, the functional complex network inferred from activity patterns is a promising way to unravel the interplay between structure and functionality of neuronal systems. Here, we monitor the spontaneous self-sustained dynamics in neuronal cultures formed by interconnected aggregates of neurons (clusters). Dynamics is characterized by the fast activation of groups of clusters in sequences termed bursts. The analysis of the time delays between clusters' activations within the bursts allows the reconstruction of the directed functional connectivity of the network. We propose a method to statistically infer this connectivity and analyze the resulting properties of the associated complex networks. Surprisingly enough, in contrast to what has been reported for many biological networks, the clustered neuronal cultures present assortative mixing connectivity values, meaning that there is a preference for clusters to link to other clusters that share similar functional connectivity, as well as a rich-club core, which shapes a 'connectivity backbone' in the network. These results point out that the grouping of neurons and the assortative connectivity between clusters are intrinsic survival mechanisms of the culture.http://europepmc.org/articles/PMC4154651?pdf=render |
| spellingShingle | Sara Teller Clara Granell Manlio De Domenico Jordi Soriano Sergio Gómez Alex Arenas Emergence of assortative mixing between clusters of cultured neurons. PLoS Computational Biology |
| title | Emergence of assortative mixing between clusters of cultured neurons. |
| title_full | Emergence of assortative mixing between clusters of cultured neurons. |
| title_fullStr | Emergence of assortative mixing between clusters of cultured neurons. |
| title_full_unstemmed | Emergence of assortative mixing between clusters of cultured neurons. |
| title_short | Emergence of assortative mixing between clusters of cultured neurons. |
| title_sort | emergence of assortative mixing between clusters of cultured neurons |
| url | http://europepmc.org/articles/PMC4154651?pdf=render |
| work_keys_str_mv | AT sarateller emergenceofassortativemixingbetweenclustersofculturedneurons AT claragranell emergenceofassortativemixingbetweenclustersofculturedneurons AT manliodedomenico emergenceofassortativemixingbetweenclustersofculturedneurons AT jordisoriano emergenceofassortativemixingbetweenclustersofculturedneurons AT sergiogomez emergenceofassortativemixingbetweenclustersofculturedneurons AT alexarenas emergenceofassortativemixingbetweenclustersofculturedneurons |