Oxidative Stress in the Pathogenesis of Antiphospholipid Syndrome: Implications for the Atherothrombotic Process
Atherothrombosis is a frequent complication of the clinical history of patients with antiphospholipid syndrome (APS). Both atherothrombosis and APS are characterized by increased oxidative stress. Oxidative modifications are implicated in the formation of antiphospholipid antibodies, which in turn m...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-11-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/10/11/1790 |
| _version_ | 1827677517460275200 |
|---|---|
| author | Cristina Nocella Simona Bartimoccia Vittoria Cammisotto Alessandra D’Amico Daniele Pastori Giacomo Frati Sebastiano Sciarretta Paolo Rosa Chiara Felici Oliviero Riggio Antonella Calogero Roberto Carnevale SMiLe Group |
| author_facet | Cristina Nocella Simona Bartimoccia Vittoria Cammisotto Alessandra D’Amico Daniele Pastori Giacomo Frati Sebastiano Sciarretta Paolo Rosa Chiara Felici Oliviero Riggio Antonella Calogero Roberto Carnevale SMiLe Group |
| author_sort | Cristina Nocella |
| collection | DOAJ |
| description | Atherothrombosis is a frequent complication of the clinical history of patients with antiphospholipid syndrome (APS). Both atherothrombosis and APS are characterized by increased oxidative stress. Oxidative modifications are implicated in the formation of antiphospholipid antibodies, which in turn may favour the oxidative imbalance by increasing the production of reactive oxidant species (ROS) or by a direct interaction with pro-oxidant/antioxidant enzymes. As a result of these processes, APS patients suffer from an oxidative imbalance that may contribute to the progression of the atherosclerotic process and to the onset of ischemic thrombotic complications. The aim of this review is to describe mechanisms implicated in the formation of ROS in APS patients and their involvement in the atherothrombotic process. We also provide an overview of potential therapeutic approaches to blunt oxidative stress and to prevent atherothrombotic complications in these patients. |
| first_indexed | 2024-03-10T05:45:07Z |
| format | Article |
| id | doaj.art-5fb7f318c7aa41db855ce0f9a17aad4c |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T05:45:07Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-5fb7f318c7aa41db855ce0f9a17aad4c2023-11-22T22:13:44ZengMDPI AGAntioxidants2076-39212021-11-011011179010.3390/antiox10111790Oxidative Stress in the Pathogenesis of Antiphospholipid Syndrome: Implications for the Atherothrombotic ProcessCristina Nocella0Simona Bartimoccia1Vittoria Cammisotto2Alessandra D’Amico3Daniele Pastori4Giacomo Frati5Sebastiano Sciarretta6Paolo Rosa7Chiara Felici8Oliviero Riggio9Antonella Calogero10Roberto Carnevale11SMiLe Group12Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, ItalyDepartment of General Surgery and Surgical Specialty Paride Stefanini, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Movement, Human and Health Sciences, University of Rome “Foro Italico”, 00135 Rome, ItalyDepartment of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, ItalyDepartment of Translational and Precision Medicine, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, ItalyFaculty of Medicine and Surgery, Course E, Sapienza University of Rome, 04100 Latina, ItalyAtherothrombosis is a frequent complication of the clinical history of patients with antiphospholipid syndrome (APS). Both atherothrombosis and APS are characterized by increased oxidative stress. Oxidative modifications are implicated in the formation of antiphospholipid antibodies, which in turn may favour the oxidative imbalance by increasing the production of reactive oxidant species (ROS) or by a direct interaction with pro-oxidant/antioxidant enzymes. As a result of these processes, APS patients suffer from an oxidative imbalance that may contribute to the progression of the atherosclerotic process and to the onset of ischemic thrombotic complications. The aim of this review is to describe mechanisms implicated in the formation of ROS in APS patients and their involvement in the atherothrombotic process. We also provide an overview of potential therapeutic approaches to blunt oxidative stress and to prevent atherothrombotic complications in these patients.https://www.mdpi.com/2076-3921/10/11/1790oxidative stressthrombosisantiphospholipid syndromeantioxidant treatment |
| spellingShingle | Cristina Nocella Simona Bartimoccia Vittoria Cammisotto Alessandra D’Amico Daniele Pastori Giacomo Frati Sebastiano Sciarretta Paolo Rosa Chiara Felici Oliviero Riggio Antonella Calogero Roberto Carnevale SMiLe Group Oxidative Stress in the Pathogenesis of Antiphospholipid Syndrome: Implications for the Atherothrombotic Process Antioxidants oxidative stress thrombosis antiphospholipid syndrome antioxidant treatment |
| title | Oxidative Stress in the Pathogenesis of Antiphospholipid Syndrome: Implications for the Atherothrombotic Process |
| title_full | Oxidative Stress in the Pathogenesis of Antiphospholipid Syndrome: Implications for the Atherothrombotic Process |
| title_fullStr | Oxidative Stress in the Pathogenesis of Antiphospholipid Syndrome: Implications for the Atherothrombotic Process |
| title_full_unstemmed | Oxidative Stress in the Pathogenesis of Antiphospholipid Syndrome: Implications for the Atherothrombotic Process |
| title_short | Oxidative Stress in the Pathogenesis of Antiphospholipid Syndrome: Implications for the Atherothrombotic Process |
| title_sort | oxidative stress in the pathogenesis of antiphospholipid syndrome implications for the atherothrombotic process |
| topic | oxidative stress thrombosis antiphospholipid syndrome antioxidant treatment |
| url | https://www.mdpi.com/2076-3921/10/11/1790 |
| work_keys_str_mv | AT cristinanocella oxidativestressinthepathogenesisofantiphospholipidsyndromeimplicationsfortheatherothromboticprocess AT simonabartimoccia oxidativestressinthepathogenesisofantiphospholipidsyndromeimplicationsfortheatherothromboticprocess AT vittoriacammisotto oxidativestressinthepathogenesisofantiphospholipidsyndromeimplicationsfortheatherothromboticprocess AT alessandradamico oxidativestressinthepathogenesisofantiphospholipidsyndromeimplicationsfortheatherothromboticprocess AT danielepastori oxidativestressinthepathogenesisofantiphospholipidsyndromeimplicationsfortheatherothromboticprocess AT giacomofrati oxidativestressinthepathogenesisofantiphospholipidsyndromeimplicationsfortheatherothromboticprocess AT sebastianosciarretta oxidativestressinthepathogenesisofantiphospholipidsyndromeimplicationsfortheatherothromboticprocess AT paolorosa oxidativestressinthepathogenesisofantiphospholipidsyndromeimplicationsfortheatherothromboticprocess AT chiarafelici oxidativestressinthepathogenesisofantiphospholipidsyndromeimplicationsfortheatherothromboticprocess AT olivieroriggio oxidativestressinthepathogenesisofantiphospholipidsyndromeimplicationsfortheatherothromboticprocess AT antonellacalogero oxidativestressinthepathogenesisofantiphospholipidsyndromeimplicationsfortheatherothromboticprocess AT robertocarnevale oxidativestressinthepathogenesisofantiphospholipidsyndromeimplicationsfortheatherothromboticprocess AT smilegroup oxidativestressinthepathogenesisofantiphospholipidsyndromeimplicationsfortheatherothromboticprocess |