Alterations in erythrocyte fatty acid composition in preclinical Alzheimer’s disease
Abstract Brain and blood fatty acids (FA) are altered in Alzheimer’s disease and cognitively impaired individuals, however, FA alterations in the preclinical phase, prior to cognitive impairment have not been investigated previously. The current study therefore evaluated erythrocyte FA in cognitivel...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-00751-2 |
| _version_ | 1818427667386466304 |
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| author | Kathryn Goozee Pratishtha Chatterjee Ian James Kaikai Shen Hamid R. Sohrabi Prita R. Asih Preeti Dave Bethany Ball Candice ManYan Kevin Taddei Roger Chung Manohar L. Garg Ralph N. Martins |
| author_facet | Kathryn Goozee Pratishtha Chatterjee Ian James Kaikai Shen Hamid R. Sohrabi Prita R. Asih Preeti Dave Bethany Ball Candice ManYan Kevin Taddei Roger Chung Manohar L. Garg Ralph N. Martins |
| author_sort | Kathryn Goozee |
| collection | DOAJ |
| description | Abstract Brain and blood fatty acids (FA) are altered in Alzheimer’s disease and cognitively impaired individuals, however, FA alterations in the preclinical phase, prior to cognitive impairment have not been investigated previously. The current study therefore evaluated erythrocyte FA in cognitively normal elderly participants aged 65–90 years via trans-methylation followed by gas chromatography. The neocortical beta-amyloid load (NAL) measured via positron emission tomography (PET) using ligand 18F-Florbetaben, was employed to categorise participants as low NAL (standard uptake value ratio; SUVR < 1.35, N = 65) and high NAL or preclinical AD (SUVR ≥ 1.35, N = 35) wherein, linear models were employed to compare FA compositions between the two groups. Increased arachidonic acid (AA, p < 0.05) and decreased docosapentaenoic acid (DPA, p < 0.05) were observed in high NAL. To differentiate low from high NAL, the area under the curve (AUC) generated from a ‘base model’ comprising age, gender, APOEε4 and education (AUC = 0.794) was outperformed by base model + AA:DPA (AUC = 0.836). Our findings suggest that specific alterations in erythrocyte FA composition occur very early in the disease pathogenic trajectory, prior to cognitive impairment. As erythrocyte FA levels are reflective of tissue FA, these alterations may provide insight into the pathogenic mechanism(s) of the disease and may highlight potential early diagnostic markers and therapeutic targets. |
| first_indexed | 2024-12-14T14:49:22Z |
| format | Article |
| id | doaj.art-5fb81ae1caec4113ad4d2005ed84ba84 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T14:49:22Z |
| publishDate | 2017-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-5fb81ae1caec4113ad4d2005ed84ba842022-12-21T22:57:11ZengNature PortfolioScientific Reports2045-23222017-04-01711910.1038/s41598-017-00751-2Alterations in erythrocyte fatty acid composition in preclinical Alzheimer’s diseaseKathryn Goozee0Pratishtha Chatterjee1Ian James2Kaikai Shen3Hamid R. Sohrabi4Prita R. Asih5Preeti Dave6Bethany Ball7Candice ManYan8Kevin Taddei9Roger Chung10Manohar L. Garg11Ralph N. Martins12AnglicareSchool of Medical and Health Sciences, Edith Cowan UniversityInstitute for Immunology & Infectious Diseases, Murdoch UniversitySchool of Medical and Health Sciences, Edith Cowan UniversitySchool of Psychiatry and Clinical Neurosciences, University of Western AustraliaKaRa Institute of Neurological DiseasesAnglicareKaRa Institute of Neurological DiseasesAnglicareSchool of Medical and Health Sciences, Edith Cowan UniversityDepartment of Biomedical Sciences, Macquarie UniversityNutraceuticals Research Program, School of Biomedical Sciences and Pharmacy, University of NewcastleSchool of Psychiatry and Clinical Neurosciences, University of Western AustraliaAbstract Brain and blood fatty acids (FA) are altered in Alzheimer’s disease and cognitively impaired individuals, however, FA alterations in the preclinical phase, prior to cognitive impairment have not been investigated previously. The current study therefore evaluated erythrocyte FA in cognitively normal elderly participants aged 65–90 years via trans-methylation followed by gas chromatography. The neocortical beta-amyloid load (NAL) measured via positron emission tomography (PET) using ligand 18F-Florbetaben, was employed to categorise participants as low NAL (standard uptake value ratio; SUVR < 1.35, N = 65) and high NAL or preclinical AD (SUVR ≥ 1.35, N = 35) wherein, linear models were employed to compare FA compositions between the two groups. Increased arachidonic acid (AA, p < 0.05) and decreased docosapentaenoic acid (DPA, p < 0.05) were observed in high NAL. To differentiate low from high NAL, the area under the curve (AUC) generated from a ‘base model’ comprising age, gender, APOEε4 and education (AUC = 0.794) was outperformed by base model + AA:DPA (AUC = 0.836). Our findings suggest that specific alterations in erythrocyte FA composition occur very early in the disease pathogenic trajectory, prior to cognitive impairment. As erythrocyte FA levels are reflective of tissue FA, these alterations may provide insight into the pathogenic mechanism(s) of the disease and may highlight potential early diagnostic markers and therapeutic targets.https://doi.org/10.1038/s41598-017-00751-2 |
| spellingShingle | Kathryn Goozee Pratishtha Chatterjee Ian James Kaikai Shen Hamid R. Sohrabi Prita R. Asih Preeti Dave Bethany Ball Candice ManYan Kevin Taddei Roger Chung Manohar L. Garg Ralph N. Martins Alterations in erythrocyte fatty acid composition in preclinical Alzheimer’s disease Scientific Reports |
| title | Alterations in erythrocyte fatty acid composition in preclinical Alzheimer’s disease |
| title_full | Alterations in erythrocyte fatty acid composition in preclinical Alzheimer’s disease |
| title_fullStr | Alterations in erythrocyte fatty acid composition in preclinical Alzheimer’s disease |
| title_full_unstemmed | Alterations in erythrocyte fatty acid composition in preclinical Alzheimer’s disease |
| title_short | Alterations in erythrocyte fatty acid composition in preclinical Alzheimer’s disease |
| title_sort | alterations in erythrocyte fatty acid composition in preclinical alzheimer s disease |
| url | https://doi.org/10.1038/s41598-017-00751-2 |
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