A 33-mRNA Classifier Is Able to Produce Inflammopathic, Adaptive, and Coagulopathic Endotypes with Prognostic Significance: The Outcomes of Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in the Early Treatment of Sepsis (ORANGES) Trial
Background: Retrospective analysis of the transcriptomic host response in sepsis has demonstrated that sepsis can be separated into three endotypes—inflammatory (IE), adaptive (AE), and coagulopathic (CE), which have demonstrated prognostic significance. We undertook a prospective transcriptomic hos...
Main Authors: | Jose Iglesias, Andrew V. Vassallo, Oliver Liesenfeld, Jerrold S. Levine, Vishal V. Patel, Jesse B. Sullivan, Joseph B. Cavanaugh, Yasmine Elbaga, Timothy E. Sweeney |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-12-01
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Series: | Journal of Personalized Medicine |
Subjects: | |
Online Access: | https://www.mdpi.com/2075-4426/11/1/9 |
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