A 33-mRNA Classifier Is Able to Produce Inflammopathic, Adaptive, and Coagulopathic Endotypes with Prognostic Significance: The Outcomes of Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in the Early Treatment of Sepsis (ORANGES) Trial

A 33-mRNA Classifier Is Able to Produce Inflammopathic, Adaptive, and Coagulopathic Endotypes with Prognostic Significance: The Outcomes of Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in the Early Treatment of Sepsis (ORANGES) Trial

Background: Retrospective analysis of the transcriptomic host response in sepsis has demonstrated that sepsis can be separated into three endotypes—inflammatory (IE), adaptive (AE), and coagulopathic (CE), which have demonstrated prognostic significance. We undertook a prospective transcriptomic hos...

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Bibliographic Details
Main Authors: Jose Iglesias, Andrew V. Vassallo, Oliver Liesenfeld, Jerrold S. Levine, Vishal V. Patel, Jesse B. Sullivan, Joseph B. Cavanaugh, Yasmine Elbaga, Timothy E. Sweeney
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Journal of Personalized Medicine
Subjects:
sepsis
septic shock
HAT therapy
vitamin c
endotyping
coagulopathic
Online Access:https://www.mdpi.com/2075-4426/11/1/9

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