IL-17A Enhances Microglial Response to OGD by Regulating p53 and PI3K/Akt Pathways with Involvement of ROS/HMGB1

IL-17A Enhances Microglial Response to OGD by Regulating p53 and PI3K/Akt Pathways with Involvement of ROS/HMGB1

Cerebral ischemia-reperfusion injury (IRI) has a complex pathogenesis, and interleukin-17 (IL-17) is a newly identified class of the cytokine family that plays an important role in ischemic inflammation. An oxygen-glucose deprivation (OGD) model showed that IL-17A expression was significantly up-reg...

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Bibliographic Details
Main Authors:	Bin Zhang, Ning Yang, Zhi-Ming Mo, Shao-Peng Lin, Feng Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-08-01
Series:	Frontiers in Molecular Neuroscience
Subjects:	IL-17A reactive oxygen species HMGB1 microglial cells cerebral ischemia-reperfusion injury proteomics
Online Access:	http://journal.frontiersin.org/article/10.3389/fnmol.2017.00271/full

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