| Summary: | In this study, the putative correlation between the molecular mobility of a polymer and the ball milling drug amorphization kinetics (i.e., time to reach full drug amorphization, <i>t</i><sub>a</sub>) was studied using different grades of dextran (Dex) and polyvinylpyrrolidone (PVP) and the two model drugs indomethacin (IND) and chloramphenicol (CAP). In general, IND had lower <i>t</i><sub>a</sub> values than CAP, indicating that IND amorphized faster than CAP in the presence of the polymers. In addition, an increase in polymer molecular weight (M<sub>w</sub>) also led to an increase in <i>t</i><sub>a</sub> for all systems investigated up to a critical M<sub>w</sub> for each polymer, which was in line with an increase of the glass transition temperature (T<sub>g</sub>) up to the critical M<sub>w</sub> of each polymer. Hence, the increase in <i>t</i><sub>a</sub> seemed to correlate well with the T<sub>g</sub>/M<sub>w</sub> of the polymers, which indicates that the polymers’ molecular mobility had an influence on the drug amorphization kinetics during ball milling.
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