Brain Connectivity Affecting Gait Function after Unilateral Supratentorial Stroke
Gait dysfunction is a leading cause of long-term disability after stroke. The mechanisms underlying recovery of gait function are unknown. We retrospectively evaluated the association between structural connectivity and gait function in 127 patients with unilateral supratentorial stroke (>1 month...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3425/11/7/870 |
| _version_ | 1797411358181949440 |
|---|---|
| author | Hyun-Ah Lee Dae-Hyun Kim |
| author_facet | Hyun-Ah Lee Dae-Hyun Kim |
| author_sort | Hyun-Ah Lee |
| collection | DOAJ |
| description | Gait dysfunction is a leading cause of long-term disability after stroke. The mechanisms underlying recovery of gait function are unknown. We retrospectively evaluated the association between structural connectivity and gait function in 127 patients with unilateral supratentorial stroke (>1 month after stroke). All patients underwent T1-weighted, diffusion tensor imaging and functional ambulation categorization. Voxel-wise linear regression analyses of the images were conducted using fractional anisotropy, mean diffusivity, and mode of anisotropy mapping as dependent variables, while the functional ambulation category was used as an independent variable with age and days after stroke as covariates. The functional ambulation category was positively associated with increased fractional anisotropy in the lesioned cortico-ponto-cerebellar system, corona radiata of the non-lesioned corticospinal tract pathway, bilateral medial lemniscus in the brainstem, and the corpus callosum. The functional ambulation category was also positively associated with increased mode of anisotropy in the lesioned posterior corpus callosum. In conclusion, structural connectivity associated with motor coordination and feedback affects gait function after stroke. Diffusion tensor imaging for evaluating structural connectivity can help to predict gait recovery and target rehabilitation goals after stroke. |
| first_indexed | 2024-03-09T04:44:53Z |
| format | Article |
| id | doaj.art-5fbab1157b054996a2135cbc9456453d |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T04:44:53Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-5fbab1157b054996a2135cbc9456453d2023-12-03T13:17:00ZengMDPI AGBrain Sciences2076-34252021-06-0111787010.3390/brainsci11070870Brain Connectivity Affecting Gait Function after Unilateral Supratentorial StrokeHyun-Ah Lee0Dae-Hyun Kim1Department of Physical Medicine and Rehabilitation, Veterans Health Service Medical Center, Seoul 05368, KoreaDepartment and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 03722, KoreaGait dysfunction is a leading cause of long-term disability after stroke. The mechanisms underlying recovery of gait function are unknown. We retrospectively evaluated the association between structural connectivity and gait function in 127 patients with unilateral supratentorial stroke (>1 month after stroke). All patients underwent T1-weighted, diffusion tensor imaging and functional ambulation categorization. Voxel-wise linear regression analyses of the images were conducted using fractional anisotropy, mean diffusivity, and mode of anisotropy mapping as dependent variables, while the functional ambulation category was used as an independent variable with age and days after stroke as covariates. The functional ambulation category was positively associated with increased fractional anisotropy in the lesioned cortico-ponto-cerebellar system, corona radiata of the non-lesioned corticospinal tract pathway, bilateral medial lemniscus in the brainstem, and the corpus callosum. The functional ambulation category was also positively associated with increased mode of anisotropy in the lesioned posterior corpus callosum. In conclusion, structural connectivity associated with motor coordination and feedback affects gait function after stroke. Diffusion tensor imaging for evaluating structural connectivity can help to predict gait recovery and target rehabilitation goals after stroke.https://www.mdpi.com/2076-3425/11/7/870strokegaitconnectivityneurorehabilitationfunctional recovery |
| spellingShingle | Hyun-Ah Lee Dae-Hyun Kim Brain Connectivity Affecting Gait Function after Unilateral Supratentorial Stroke Brain Sciences stroke gait connectivity neurorehabilitation functional recovery |
| title | Brain Connectivity Affecting Gait Function after Unilateral Supratentorial Stroke |
| title_full | Brain Connectivity Affecting Gait Function after Unilateral Supratentorial Stroke |
| title_fullStr | Brain Connectivity Affecting Gait Function after Unilateral Supratentorial Stroke |
| title_full_unstemmed | Brain Connectivity Affecting Gait Function after Unilateral Supratentorial Stroke |
| title_short | Brain Connectivity Affecting Gait Function after Unilateral Supratentorial Stroke |
| title_sort | brain connectivity affecting gait function after unilateral supratentorial stroke |
| topic | stroke gait connectivity neurorehabilitation functional recovery |
| url | https://www.mdpi.com/2076-3425/11/7/870 |
| work_keys_str_mv | AT hyunahlee brainconnectivityaffectinggaitfunctionafterunilateralsupratentorialstroke AT daehyunkim brainconnectivityaffectinggaitfunctionafterunilateralsupratentorialstroke |