Pathogenesis of Keratinocyte Carcinomas and the Therapeutic Potential of Medicinal Plants and Phytochemicals
Keratinocyte carcinoma (KC) is a form of skin cancer that develops in keratinocytes, which are the predominant cells present in the epidermis layer of the skin. Keratinocyte carcinoma comprises two sub-types, namely basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). This review provides a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/7/1979 |
| _version_ | 1797539262630985728 |
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| author | Andrea Jess Josiah Danielle Twilley Sreejarani Kesavan Pillai Suprakas Sinha Ray Namrita Lall |
| author_facet | Andrea Jess Josiah Danielle Twilley Sreejarani Kesavan Pillai Suprakas Sinha Ray Namrita Lall |
| author_sort | Andrea Jess Josiah |
| collection | DOAJ |
| description | Keratinocyte carcinoma (KC) is a form of skin cancer that develops in keratinocytes, which are the predominant cells present in the epidermis layer of the skin. Keratinocyte carcinoma comprises two sub-types, namely basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). This review provides a holistic literature assessment of the origin, diagnosis methods, contributing factors, and current topical treatments of KC. Additionally, it explores the increase in KC cases that occurred globally over the past ten years. One of the principal concepts highlighted in this article is the adverse effects linked to conventional treatment methods of KC and how novel treatment strategies that combine phytochemistry and transdermal drug delivery systems offer an alternative approach for treatment. However, more in vitro and in vivo studies are required to fully assess the efficacy, mechanism of action, and safety profile of these phytochemical based transdermal chemotherapeutics. |
| first_indexed | 2024-03-10T12:43:29Z |
| format | Article |
| id | doaj.art-5fbc37a4f2da4a54b70564e47f3a8a21 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T12:43:29Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5fbc37a4f2da4a54b70564e47f3a8a212023-11-21T13:42:00ZengMDPI AGMolecules1420-30492021-04-01267197910.3390/molecules26071979Pathogenesis of Keratinocyte Carcinomas and the Therapeutic Potential of Medicinal Plants and PhytochemicalsAndrea Jess Josiah0Danielle Twilley1Sreejarani Kesavan Pillai2Suprakas Sinha Ray3Namrita Lall4DST-CSIR National Centre for Nanostructured Materials, Council for Scientific and Industrial Research, Pretoria 0001, South AfricaDepartment of Plant and Soil Sciences, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria 0002, South AfricaDST-CSIR National Centre for Nanostructured Materials, Council for Scientific and Industrial Research, Pretoria 0001, South AfricaDST-CSIR National Centre for Nanostructured Materials, Council for Scientific and Industrial Research, Pretoria 0001, South AfricaDepartment of Plant and Soil Sciences, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria 0002, South AfricaKeratinocyte carcinoma (KC) is a form of skin cancer that develops in keratinocytes, which are the predominant cells present in the epidermis layer of the skin. Keratinocyte carcinoma comprises two sub-types, namely basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). This review provides a holistic literature assessment of the origin, diagnosis methods, contributing factors, and current topical treatments of KC. Additionally, it explores the increase in KC cases that occurred globally over the past ten years. One of the principal concepts highlighted in this article is the adverse effects linked to conventional treatment methods of KC and how novel treatment strategies that combine phytochemistry and transdermal drug delivery systems offer an alternative approach for treatment. However, more in vitro and in vivo studies are required to fully assess the efficacy, mechanism of action, and safety profile of these phytochemical based transdermal chemotherapeutics.https://www.mdpi.com/1420-3049/26/7/1979keratinocyte carcinomamedicinal plantsphytochemistrytransdermal drug delivery systems |
| spellingShingle | Andrea Jess Josiah Danielle Twilley Sreejarani Kesavan Pillai Suprakas Sinha Ray Namrita Lall Pathogenesis of Keratinocyte Carcinomas and the Therapeutic Potential of Medicinal Plants and Phytochemicals Molecules keratinocyte carcinoma medicinal plants phytochemistry transdermal drug delivery systems |
| title | Pathogenesis of Keratinocyte Carcinomas and the Therapeutic Potential of Medicinal Plants and Phytochemicals |
| title_full | Pathogenesis of Keratinocyte Carcinomas and the Therapeutic Potential of Medicinal Plants and Phytochemicals |
| title_fullStr | Pathogenesis of Keratinocyte Carcinomas and the Therapeutic Potential of Medicinal Plants and Phytochemicals |
| title_full_unstemmed | Pathogenesis of Keratinocyte Carcinomas and the Therapeutic Potential of Medicinal Plants and Phytochemicals |
| title_short | Pathogenesis of Keratinocyte Carcinomas and the Therapeutic Potential of Medicinal Plants and Phytochemicals |
| title_sort | pathogenesis of keratinocyte carcinomas and the therapeutic potential of medicinal plants and phytochemicals |
| topic | keratinocyte carcinoma medicinal plants phytochemistry transdermal drug delivery systems |
| url | https://www.mdpi.com/1420-3049/26/7/1979 |
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