INDIRECT MEASURES OF NEUROPROTECTION ARE PARAMETERS TO AVOID: EXAMPLES FROM RESEARCH ON NEONATAL RAT HYPOXIA-ISCHEMIA
The use of indirect measures of neuronal injury or neuroprotection, such as brain weight or the neuronal density of neurons, can lead to misinterpretations of biological processes. The use of modern stereological methods to directly measure the absolute number of surviving neurons generally yields m...
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| Format: | Article |
| Language: | English |
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Slovenian Society for Stereology and Quantitative Image Analysis
2011-03-01
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| Series: | Image Analysis and Stereology |
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| Online Access: | http://www.ias-iss.org/ojs/IAS/article/view/18 |
| _version_ | 1819141794633351168 |
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| author | Dorothy E Oorschot |
| author_facet | Dorothy E Oorschot |
| author_sort | Dorothy E Oorschot |
| collection | DOAJ |
| description | The use of indirect measures of neuronal injury or neuroprotection, such as brain weight or the neuronal density of neurons, can lead to misinterpretations of biological processes. The use of modern stereological methods to directly measure the absolute number of surviving neurons generally yields more reliable conclusions. The aim of this review is to provide some worked examples of this principle. The worked examples are obtained from research completed over the past 13 years on the investigation of potential neuroprotective therapies for moderate brain injury after neonatal hypoxia-ischemia in the rat. |
| first_indexed | 2024-12-22T12:00:07Z |
| format | Article |
| id | doaj.art-5fbd1808361c48afa37545f1bd7ed247 |
| institution | Directory Open Access Journal |
| issn | 1580-3139 1854-5165 |
| language | English |
| last_indexed | 2024-12-22T12:00:07Z |
| publishDate | 2011-03-01 |
| publisher | Slovenian Society for Stereology and Quantitative Image Analysis |
| record_format | Article |
| series | Image Analysis and Stereology |
| spelling | doaj.art-5fbd1808361c48afa37545f1bd7ed2472022-12-21T18:26:39ZengSlovenian Society for Stereology and Quantitative Image AnalysisImage Analysis and Stereology1580-31391854-51652011-03-013011910.5566/ias.v30.p1-96INDIRECT MEASURES OF NEUROPROTECTION ARE PARAMETERS TO AVOID: EXAMPLES FROM RESEARCH ON NEONATAL RAT HYPOXIA-ISCHEMIADorothy E OorschotThe use of indirect measures of neuronal injury or neuroprotection, such as brain weight or the neuronal density of neurons, can lead to misinterpretations of biological processes. The use of modern stereological methods to directly measure the absolute number of surviving neurons generally yields more reliable conclusions. The aim of this review is to provide some worked examples of this principle. The worked examples are obtained from research completed over the past 13 years on the investigation of potential neuroprotective therapies for moderate brain injury after neonatal hypoxia-ischemia in the rat.http://www.ias-iss.org/ojs/IAS/article/view/18absolute neuronal numberbrain weightCavalieri’s methodneuronal densityoptical disectorstereology |
| spellingShingle | Dorothy E Oorschot INDIRECT MEASURES OF NEUROPROTECTION ARE PARAMETERS TO AVOID: EXAMPLES FROM RESEARCH ON NEONATAL RAT HYPOXIA-ISCHEMIA Image Analysis and Stereology absolute neuronal number brain weight Cavalieri’s method neuronal density optical disector stereology |
| title | INDIRECT MEASURES OF NEUROPROTECTION ARE PARAMETERS TO AVOID: EXAMPLES FROM RESEARCH ON NEONATAL RAT HYPOXIA-ISCHEMIA |
| title_full | INDIRECT MEASURES OF NEUROPROTECTION ARE PARAMETERS TO AVOID: EXAMPLES FROM RESEARCH ON NEONATAL RAT HYPOXIA-ISCHEMIA |
| title_fullStr | INDIRECT MEASURES OF NEUROPROTECTION ARE PARAMETERS TO AVOID: EXAMPLES FROM RESEARCH ON NEONATAL RAT HYPOXIA-ISCHEMIA |
| title_full_unstemmed | INDIRECT MEASURES OF NEUROPROTECTION ARE PARAMETERS TO AVOID: EXAMPLES FROM RESEARCH ON NEONATAL RAT HYPOXIA-ISCHEMIA |
| title_short | INDIRECT MEASURES OF NEUROPROTECTION ARE PARAMETERS TO AVOID: EXAMPLES FROM RESEARCH ON NEONATAL RAT HYPOXIA-ISCHEMIA |
| title_sort | indirect measures of neuroprotection are parameters to avoid examples from research on neonatal rat hypoxia ischemia |
| topic | absolute neuronal number brain weight Cavalieri’s method neuronal density optical disector stereology |
| url | http://www.ias-iss.org/ojs/IAS/article/view/18 |
| work_keys_str_mv | AT dorothyeoorschot indirectmeasuresofneuroprotectionareparameterstoavoidexamplesfromresearchonneonatalrathypoxiaischemia |