Reserpine for the treatment of refractory mania
We report a case of refractory mania treated successfully with reserpine. The patient was a 26-year-old man with bipolar I disorder, who had recurrent hospital admissions for manic episodes that failed to respond to multiple mood stabilisers and antipsychotics. The patient also suffered from hyperte...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
AOSIS
2014-04-01
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| Series: | South African Journal of Psychiatry |
| Subjects: | |
| Online Access: | http://www.sajp.org.za/index.php/sajp/article/view/456 |
| _version_ | 1811291994114228224 |
|---|---|
| author | Ingrid Geeske Eloff Willem Esterhuysen |
| author_facet | Ingrid Geeske Eloff Willem Esterhuysen |
| author_sort | Ingrid Geeske Eloff |
| collection | DOAJ |
| description | We report a case of refractory mania treated successfully with reserpine. The patient was a 26-year-old man with bipolar I disorder, who had recurrent hospital admissions for manic episodes that failed to respond to multiple mood stabilisers and antipsychotics. The patient also suffered from hypertension. His manic symptoms improved markedly with the addition of reserpine to the treatment regimen. Reserpine is a centrally acting antihypertensive with anti-adrenergic properties. It has been found to reduce the duration of a manic episode rapidly in a small group of studies. This proved to be the case with this patient. Reserpine used in conjunction with other psychotropic medication may be considered in the treatment of refractory mania, but controlled trials are necessary to support our finding more generally. |
| first_indexed | 2024-04-13T04:37:46Z |
| format | Article |
| id | doaj.art-5fbd645969e64cc68eddf33a6d3aec8d |
| institution | Directory Open Access Journal |
| issn | 1608-9685 2078-6786 |
| language | English |
| last_indexed | 2024-04-13T04:37:46Z |
| publishDate | 2014-04-01 |
| publisher | AOSIS |
| record_format | Article |
| series | South African Journal of Psychiatry |
| spelling | doaj.art-5fbd645969e64cc68eddf33a6d3aec8d2022-12-22T03:02:06ZengAOSISSouth African Journal of Psychiatry1608-96852078-67862014-04-01201e1e210.4102/sajpsychiatry.v20i1.45614Reserpine for the treatment of refractory maniaIngrid Geeske Eloff0Willem Esterhuysen1Department of Psychiatry, Elizabeth Donkin Hospital, Walter Sisulu University, Port Elizabeth, South AfricaDepartment of Psychiatry, Elizabeth Donkin Hospital, Walter Sisulu University, Port Elizabeth, South AfricaWe report a case of refractory mania treated successfully with reserpine. The patient was a 26-year-old man with bipolar I disorder, who had recurrent hospital admissions for manic episodes that failed to respond to multiple mood stabilisers and antipsychotics. The patient also suffered from hypertension. His manic symptoms improved markedly with the addition of reserpine to the treatment regimen. Reserpine is a centrally acting antihypertensive with anti-adrenergic properties. It has been found to reduce the duration of a manic episode rapidly in a small group of studies. This proved to be the case with this patient. Reserpine used in conjunction with other psychotropic medication may be considered in the treatment of refractory mania, but controlled trials are necessary to support our finding more generally.http://www.sajp.org.za/index.php/sajp/article/view/456bipolar disorder type 1maniarefractory maniareserpine |
| spellingShingle | Ingrid Geeske Eloff Willem Esterhuysen Reserpine for the treatment of refractory mania South African Journal of Psychiatry bipolar disorder type 1 mania refractory mania reserpine |
| title | Reserpine for the treatment of refractory mania |
| title_full | Reserpine for the treatment of refractory mania |
| title_fullStr | Reserpine for the treatment of refractory mania |
| title_full_unstemmed | Reserpine for the treatment of refractory mania |
| title_short | Reserpine for the treatment of refractory mania |
| title_sort | reserpine for the treatment of refractory mania |
| topic | bipolar disorder type 1 mania refractory mania reserpine |
| url | http://www.sajp.org.za/index.php/sajp/article/view/456 |
| work_keys_str_mv | AT ingridgeeskeeloff reserpineforthetreatmentofrefractorymania AT willemesterhuysen reserpineforthetreatmentofrefractorymania |