NLRP1- A CINDERELLA STORY: a perspective of recent advances in NLRP1 and the questions they raise
Abstract NLRP1, while the first inflammasome described, has only recently begun to gain significant attention in disease pathology, inflammation research, and potentially, as a therapeutic target. Recently identified human variants provide key insights into NLRP1 biology while its unique expression...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-12-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-05684-3 |
| _version_ | 1797388129541292032 |
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| author | Kristian Barry Christopher Murphy Ashley Mansell |
| author_facet | Kristian Barry Christopher Murphy Ashley Mansell |
| author_sort | Kristian Barry |
| collection | DOAJ |
| description | Abstract NLRP1, while the first inflammasome described, has only recently begun to gain significant attention in disease pathology, inflammation research, and potentially, as a therapeutic target. Recently identified human variants provide key insights into NLRP1 biology while its unique expression in barrier cells such as keratinocytes and airway epithelial cells has aligned with new, human specific agonists. This differentiates NLRP1 from other inflammasomes such as NLRP3 and identifies it as a key therapeutic target in inflammatory diseases. Indeed, recent discoveries highlight that NLRP1 may be the predominant inflammasome in human barrier cells, its primary role akin to NLRP3, to respond to cellular stress. This review focuses on recent studies identifying new human-specific NLRP1 mechanisms of activation of, gain-of-function human variants and disease, its role in responding to cellular stress, and discuss potential advances and the therapeutic potential for NLRP1. |
| first_indexed | 2024-03-08T22:36:23Z |
| format | Article |
| id | doaj.art-5fbe5dea1c804a6abf8ecaef3abd03fc |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-03-08T22:36:23Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-5fbe5dea1c804a6abf8ecaef3abd03fc2023-12-17T12:27:06ZengNature PortfolioCommunications Biology2399-36422023-12-01611710.1038/s42003-023-05684-3NLRP1- A CINDERELLA STORY: a perspective of recent advances in NLRP1 and the questions they raiseKristian Barry0Christopher Murphy1Ashley Mansell2Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research7 Warren St.Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical ResearchAbstract NLRP1, while the first inflammasome described, has only recently begun to gain significant attention in disease pathology, inflammation research, and potentially, as a therapeutic target. Recently identified human variants provide key insights into NLRP1 biology while its unique expression in barrier cells such as keratinocytes and airway epithelial cells has aligned with new, human specific agonists. This differentiates NLRP1 from other inflammasomes such as NLRP3 and identifies it as a key therapeutic target in inflammatory diseases. Indeed, recent discoveries highlight that NLRP1 may be the predominant inflammasome in human barrier cells, its primary role akin to NLRP3, to respond to cellular stress. This review focuses on recent studies identifying new human-specific NLRP1 mechanisms of activation of, gain-of-function human variants and disease, its role in responding to cellular stress, and discuss potential advances and the therapeutic potential for NLRP1.https://doi.org/10.1038/s42003-023-05684-3 |
| spellingShingle | Kristian Barry Christopher Murphy Ashley Mansell NLRP1- A CINDERELLA STORY: a perspective of recent advances in NLRP1 and the questions they raise Communications Biology |
| title | NLRP1- A CINDERELLA STORY: a perspective of recent advances in NLRP1 and the questions they raise |
| title_full | NLRP1- A CINDERELLA STORY: a perspective of recent advances in NLRP1 and the questions they raise |
| title_fullStr | NLRP1- A CINDERELLA STORY: a perspective of recent advances in NLRP1 and the questions they raise |
| title_full_unstemmed | NLRP1- A CINDERELLA STORY: a perspective of recent advances in NLRP1 and the questions they raise |
| title_short | NLRP1- A CINDERELLA STORY: a perspective of recent advances in NLRP1 and the questions they raise |
| title_sort | nlrp1 a cinderella story a perspective of recent advances in nlrp1 and the questions they raise |
| url | https://doi.org/10.1038/s42003-023-05684-3 |
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