Implications of Tioguanine Dosing in IBD Patients with a TPMT Deficiency

Implications of Tioguanine Dosing in IBD Patients with a TPMT Deficiency

Tioguanine is metabolised by fewer enzymatic steps compared to azathioprine and mercaptopurine, without generating 6-methylmercaptopurine ribonucleotides. However, thiopurine S-methyl transferase (TPMT) plays a role in early toxicity in all thiopurines. We aimed to describe the hazards and opportuni...

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Bibliographic Details
Main Authors: Debbie S. Deben, Luc J. J. Derijks, Bianca J. C. van den Bosch, Rob H. Creemers, Annick van Nunen, Adriaan A. van Bodegraven, Dennis R. Wong
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Metabolites
Subjects:
thiopurine S-methyl transferase (TPMT)
tioguanine
inflammatory bowel disease (IBD)
TPMT deficiency
Online Access:https://www.mdpi.com/2218-1989/13/10/1054

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