Protective to a T: The Role of T Cells during Zika Virus Infection
CD4 and CD8 T cells are an important part of the host’s capacity to defend itself against viral infections. During <i>flavivirus</i> infections, T cells have been implicated in both protective and pathogenic responses. Given the recent emergence of Zika virus (ZIKV) as a promin...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/8/820 |
| _version_ | 1797707528441692160 |
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| author | Ryan D. Pardy Martin J. Richer |
| author_facet | Ryan D. Pardy Martin J. Richer |
| author_sort | Ryan D. Pardy |
| collection | DOAJ |
| description | CD4 and CD8 T cells are an important part of the host’s capacity to defend itself against viral infections. During <i>flavivirus</i> infections, T cells have been implicated in both protective and pathogenic responses. Given the recent emergence of Zika virus (ZIKV) as a prominent global health threat, the question remains as to how T cells contribute to anti-ZIKV immunity. Furthermore, high homology between ZIKV and other, co-circulating <i>flaviviruses</i> opens the possibility of positive or negative effects of cross-reactivity due to pre-existing immunity. In this review, we will discuss the CD4 and CD8 T cell responses to ZIKV, and the lessons we have learned from both mouse and human infections. In addition, we will consider the possibility of whether T cells, in the context of <i>flavivirus</i>-naïve and <i>flavivirus</i>-immune subjects, play a role in promoting ZIKV pathogenesis during infection. |
| first_indexed | 2024-03-12T06:07:41Z |
| format | Article |
| id | doaj.art-5fc012978ea143d58b10d80d3ed7d0f2 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T06:07:41Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-5fc012978ea143d58b10d80d3ed7d0f22023-09-03T03:25:34ZengMDPI AGCells2073-44092019-08-018882010.3390/cells8080820cells8080820Protective to a T: The Role of T Cells during Zika Virus InfectionRyan D. Pardy0Martin J. Richer1Department of Microbiology & Immunology, McGill University, Montreal, QC H3A 2B4, CanadaDepartment of Microbiology & Immunology, McGill University, Montreal, QC H3A 2B4, CanadaCD4 and CD8 T cells are an important part of the host’s capacity to defend itself against viral infections. During <i>flavivirus</i> infections, T cells have been implicated in both protective and pathogenic responses. Given the recent emergence of Zika virus (ZIKV) as a prominent global health threat, the question remains as to how T cells contribute to anti-ZIKV immunity. Furthermore, high homology between ZIKV and other, co-circulating <i>flaviviruses</i> opens the possibility of positive or negative effects of cross-reactivity due to pre-existing immunity. In this review, we will discuss the CD4 and CD8 T cell responses to ZIKV, and the lessons we have learned from both mouse and human infections. In addition, we will consider the possibility of whether T cells, in the context of <i>flavivirus</i>-naïve and <i>flavivirus</i>-immune subjects, play a role in promoting ZIKV pathogenesis during infection.https://www.mdpi.com/2073-4409/8/8/820zika virusflavivirusesT cellshost-pathogen interactions |
| spellingShingle | Ryan D. Pardy Martin J. Richer Protective to a T: The Role of T Cells during Zika Virus Infection Cells zika virus flaviviruses T cells host-pathogen interactions |
| title | Protective to a T: The Role of T Cells during Zika Virus Infection |
| title_full | Protective to a T: The Role of T Cells during Zika Virus Infection |
| title_fullStr | Protective to a T: The Role of T Cells during Zika Virus Infection |
| title_full_unstemmed | Protective to a T: The Role of T Cells during Zika Virus Infection |
| title_short | Protective to a T: The Role of T Cells during Zika Virus Infection |
| title_sort | protective to a t the role of t cells during zika virus infection |
| topic | zika virus flaviviruses T cells host-pathogen interactions |
| url | https://www.mdpi.com/2073-4409/8/8/820 |
| work_keys_str_mv | AT ryandpardy protectivetoattheroleoftcellsduringzikavirusinfection AT martinjricher protectivetoattheroleoftcellsduringzikavirusinfection |