The Role of Taurine in Skeletal Muscle Functioning and Its Potential as a Supportive Treatment for Duchenne Muscular Dystrophy
Taurine (2-aminoethanesulfonic acid) is required for ensuring proper muscle functioning. Knockout of the taurine transporter in mice results in low taurine concentrations in the muscle and associates with myofiber necrosis and diminished exercise capacity. Interestingly, regulation of taurine and it...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/2/193 |
| _version_ | 1797478050662711296 |
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| author | Caroline Merckx Boel De Paepe |
| author_facet | Caroline Merckx Boel De Paepe |
| author_sort | Caroline Merckx |
| collection | DOAJ |
| description | Taurine (2-aminoethanesulfonic acid) is required for ensuring proper muscle functioning. Knockout of the taurine transporter in mice results in low taurine concentrations in the muscle and associates with myofiber necrosis and diminished exercise capacity. Interestingly, regulation of taurine and its transporter is altered in the mdx mouse, a model for Duchenne Muscular Dystrophy (DMD). DMD is a genetic disorder characterized by progressive muscle degeneration and weakness due to the absence of dystrophin from the muscle membrane, causing destabilization and contraction-induced muscle cell damage. This review explores the physiological role of taurine in skeletal muscle and the consequences of a disturbed balance in DMD. Its potential as a supportive treatment for DMD is also discussed. In addition to genetic correction, that is currently under development as a curative treatment, taurine supplementation has the potential to reduce muscle inflammation and improve muscle strength in patients. |
| first_indexed | 2024-03-09T21:26:32Z |
| format | Article |
| id | doaj.art-5fc11235ddd841d5b2b1a4e775600738 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T21:26:32Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-5fc11235ddd841d5b2b1a4e7756007382023-11-23T21:05:55ZengMDPI AGMetabolites2218-19892022-02-0112219310.3390/metabo12020193The Role of Taurine in Skeletal Muscle Functioning and Its Potential as a Supportive Treatment for Duchenne Muscular DystrophyCaroline Merckx0Boel De Paepe1Department of Neurology, Ghent University Hospital, 9000 Ghent, BelgiumDepartment of Neurology, Ghent University Hospital, 9000 Ghent, BelgiumTaurine (2-aminoethanesulfonic acid) is required for ensuring proper muscle functioning. Knockout of the taurine transporter in mice results in low taurine concentrations in the muscle and associates with myofiber necrosis and diminished exercise capacity. Interestingly, regulation of taurine and its transporter is altered in the mdx mouse, a model for Duchenne Muscular Dystrophy (DMD). DMD is a genetic disorder characterized by progressive muscle degeneration and weakness due to the absence of dystrophin from the muscle membrane, causing destabilization and contraction-induced muscle cell damage. This review explores the physiological role of taurine in skeletal muscle and the consequences of a disturbed balance in DMD. Its potential as a supportive treatment for DMD is also discussed. In addition to genetic correction, that is currently under development as a curative treatment, taurine supplementation has the potential to reduce muscle inflammation and improve muscle strength in patients.https://www.mdpi.com/2218-1989/12/2/193taurineosmolytesmuscleDuchenne Muscular Dystrophymdx |
| spellingShingle | Caroline Merckx Boel De Paepe The Role of Taurine in Skeletal Muscle Functioning and Its Potential as a Supportive Treatment for Duchenne Muscular Dystrophy Metabolites taurine osmolytes muscle Duchenne Muscular Dystrophy mdx |
| title | The Role of Taurine in Skeletal Muscle Functioning and Its Potential as a Supportive Treatment for Duchenne Muscular Dystrophy |
| title_full | The Role of Taurine in Skeletal Muscle Functioning and Its Potential as a Supportive Treatment for Duchenne Muscular Dystrophy |
| title_fullStr | The Role of Taurine in Skeletal Muscle Functioning and Its Potential as a Supportive Treatment for Duchenne Muscular Dystrophy |
| title_full_unstemmed | The Role of Taurine in Skeletal Muscle Functioning and Its Potential as a Supportive Treatment for Duchenne Muscular Dystrophy |
| title_short | The Role of Taurine in Skeletal Muscle Functioning and Its Potential as a Supportive Treatment for Duchenne Muscular Dystrophy |
| title_sort | role of taurine in skeletal muscle functioning and its potential as a supportive treatment for duchenne muscular dystrophy |
| topic | taurine osmolytes muscle Duchenne Muscular Dystrophy mdx |
| url | https://www.mdpi.com/2218-1989/12/2/193 |
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