Paracrine signaling of ferroptotic airway epithelium in crystalline silica-induced pulmonary fibrosis augments local fibroblast activation through glycolysis reprogramming

Paracrine signaling of ferroptotic airway epithelium in crystalline silica-induced pulmonary fibrosis augments local fibroblast activation through glycolysis reprogramming

Chronic exposure to crystalline silica (CS) contributes to pulmonary fibrosis. Airway epithelium dysfunction and fibroblast activation have both been recognized as pivotal players, alongside disturbances in ferroptosis and glycolysis reprogramming. However, the mechanisms involved remain unclear. In...

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Bibliographic Details
Main Authors: Qianmin Li, Yi Ling, Yu Ma, Tao Zhang, Youjing Yang, Shasha Tao
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Crystalline silica
Paracrine signaling
Ferroptosis
Glycolysis reprogramming
AMPK-Glut1 axis
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651324000691

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http://www.sciencedirect.com/science/article/pii/S0147651324000691

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