Functionalizable Glyconanoparticles for a Versatile Redox Platform
A series of new glyconanoparticles (GNPs) was obtained by self-assembly by direct nanoprecipitation of a mixture of two carbohydrate amphiphilic copolymers consisting of polystyrene-block-β-cyclodextrin and polystyrene-block-maltoheptaose with different mass ratios, respectively 0–100, 10–90, 50–50...
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| Format: | Article |
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MDPI AG
2021-04-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/11/5/1162 |
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| author | Marie Carrière Paulo Henrique M. Buzzetti Karine Gorgy Muhammad Mumtaz Christophe Travelet Redouane Borsali Serge Cosnier |
| author_facet | Marie Carrière Paulo Henrique M. Buzzetti Karine Gorgy Muhammad Mumtaz Christophe Travelet Redouane Borsali Serge Cosnier |
| author_sort | Marie Carrière |
| collection | DOAJ |
| description | A series of new glyconanoparticles (GNPs) was obtained by self-assembly by direct nanoprecipitation of a mixture of two carbohydrate amphiphilic copolymers consisting of polystyrene-block-β-cyclodextrin and polystyrene-block-maltoheptaose with different mass ratios, respectively 0–100, 10–90, 50–50 and 0–100%. Characterizations for all these GNPs were achieved using dynamic light scattering, scanning and transmission electron microscopy techniques, highlighting their spherical morphology and their nanometric size (diameter range 20–40 nm). In addition, by using the inclusion properties of cyclodextrin, these glyconanoparticles were successfully post-functionalized using a water-soluble redox compound, such as anthraquinone sulfonate (AQS) and characterized by cyclic voltammetry. The resulting glyconanoparticles exhibit the classical electroactivity of free AQS in solution. The amount of AQS immobilized by host–guest interactions is proportional to the percentage of polystyrene-block-β-cyclodextrin entering into the composition of GNPs. The modulation of the surface density of the β-cyclodextrin at the shell of the GNPs may constitute an attractive way for the elaboration of different electroactive GNPs and even GNPs modified by biotinylated proteins. |
| first_indexed | 2024-03-10T11:51:04Z |
| format | Article |
| id | doaj.art-5fc26a694b154ae4b02a018853af0b05 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T11:51:04Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-5fc26a694b154ae4b02a018853af0b052023-11-21T17:42:51ZengMDPI AGNanomaterials2079-49912021-04-01115116210.3390/nano11051162Functionalizable Glyconanoparticles for a Versatile Redox PlatformMarie Carrière0Paulo Henrique M. Buzzetti1Karine Gorgy2Muhammad Mumtaz3Christophe Travelet4Redouane Borsali5Serge Cosnier6UMR 5250, Département de Chimie Moléculaire, CNRS, Université Grenoble Alpes, CEDEX 09, 38058 Grenoble, FranceUMR 5250, Département de Chimie Moléculaire, CNRS, Université Grenoble Alpes, CEDEX 09, 38058 Grenoble, FranceUMR 5250, Département de Chimie Moléculaire, CNRS, Université Grenoble Alpes, CEDEX 09, 38058 Grenoble, FranceCERMAV, UPR 5301, CNRS, Université Grenoble Alpes, CEDEX 09, 38058 Grenoble, FranceCERMAV, UPR 5301, CNRS, Université Grenoble Alpes, CEDEX 09, 38058 Grenoble, FranceCERMAV, UPR 5301, CNRS, Université Grenoble Alpes, CEDEX 09, 38058 Grenoble, FranceUMR 5250, Département de Chimie Moléculaire, CNRS, Université Grenoble Alpes, CEDEX 09, 38058 Grenoble, FranceA series of new glyconanoparticles (GNPs) was obtained by self-assembly by direct nanoprecipitation of a mixture of two carbohydrate amphiphilic copolymers consisting of polystyrene-block-β-cyclodextrin and polystyrene-block-maltoheptaose with different mass ratios, respectively 0–100, 10–90, 50–50 and 0–100%. Characterizations for all these GNPs were achieved using dynamic light scattering, scanning and transmission electron microscopy techniques, highlighting their spherical morphology and their nanometric size (diameter range 20–40 nm). In addition, by using the inclusion properties of cyclodextrin, these glyconanoparticles were successfully post-functionalized using a water-soluble redox compound, such as anthraquinone sulfonate (AQS) and characterized by cyclic voltammetry. The resulting glyconanoparticles exhibit the classical electroactivity of free AQS in solution. The amount of AQS immobilized by host–guest interactions is proportional to the percentage of polystyrene-block-β-cyclodextrin entering into the composition of GNPs. The modulation of the surface density of the β-cyclodextrin at the shell of the GNPs may constitute an attractive way for the elaboration of different electroactive GNPs and even GNPs modified by biotinylated proteins.https://www.mdpi.com/2079-4991/11/5/1162glyconanoparticlesblock copolymerβ-cyclodextrinmaltoheptaosehost–guest interactionanthraquinone sulfonate |
| spellingShingle | Marie Carrière Paulo Henrique M. Buzzetti Karine Gorgy Muhammad Mumtaz Christophe Travelet Redouane Borsali Serge Cosnier Functionalizable Glyconanoparticles for a Versatile Redox Platform Nanomaterials glyconanoparticles block copolymer β-cyclodextrin maltoheptaose host–guest interaction anthraquinone sulfonate |
| title | Functionalizable Glyconanoparticles for a Versatile Redox Platform |
| title_full | Functionalizable Glyconanoparticles for a Versatile Redox Platform |
| title_fullStr | Functionalizable Glyconanoparticles for a Versatile Redox Platform |
| title_full_unstemmed | Functionalizable Glyconanoparticles for a Versatile Redox Platform |
| title_short | Functionalizable Glyconanoparticles for a Versatile Redox Platform |
| title_sort | functionalizable glyconanoparticles for a versatile redox platform |
| topic | glyconanoparticles block copolymer β-cyclodextrin maltoheptaose host–guest interaction anthraquinone sulfonate |
| url | https://www.mdpi.com/2079-4991/11/5/1162 |
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