OPCML is a broad tumor suppressor for multiple carcinomas and lymphomas with frequently epigenetic inactivation.

OPCML is a broad tumor suppressor for multiple carcinomas and lymphomas with frequently epigenetic inactivation.

Identification of tumor suppressor genes (TSGs) silenced by CpG methylation uncovers the molecular mechanism of tumorigenesis and potential tumor biomarkers. Loss of heterozygosity at 11q25 is common in multiple tumors including nasopharyngeal carcinoma (NPC). OPCML, located at 11q25, is one of the...

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Main Authors: Yan Cui, Ying Ying, Andrew van Hasselt, Ka Man Ng, Jun Yu, Qian Zhang, Jie Jin, Dingxie Liu, Johng S Rhim, Sun Young Rha, Myriam Loyo, Anthony T C Chan, Gopesh Srivastava, George S W Tsao, Grant C Sellar, Joseph J Y Sung, David Sidransky, Qian Tao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2500176?pdf=render

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