Short-term effect of 0.01% atropine sulphate eye gel on myopia progression in children
AIM: To investigate the effect of 0.01% atropine sulphate eye gel on myopia progression and axial elongation in a 6-month treatment in children. METHODS: Totally 185 children aged 6-12y with binocular myopia of 3.0 D or less in both eyes were enrolled in this prospective cohort study. The atropine g...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2022-07-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://ies.ijo.cn/en_publish/2022/7/20220712.pdf |
| _version_ | 1818218178702999552 |
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| author | Shi-Yin Pan Yang-Zheng Wang Jun Li Xue-Hui Zhang Jin Wang Xiu-Ping Zhu Xiang-Hua Xiao Jun-Tian Liu |
| author_facet | Shi-Yin Pan Yang-Zheng Wang Jun Li Xue-Hui Zhang Jin Wang Xiu-Ping Zhu Xiang-Hua Xiao Jun-Tian Liu |
| author_sort | Shi-Yin Pan |
| collection | DOAJ |
| description | AIM: To investigate the effect of 0.01% atropine sulphate eye gel on myopia progression and axial elongation in a 6-month treatment in children. METHODS: Totally 185 children aged 6-12y with binocular myopia of 3.0 D or less in both eyes were enrolled in this prospective cohort study. The atropine group (n=125) received one drop of 0.01% atropine sulphate eye gel in each eye before bedtime daily. The control group included 60 matched children without drug intervention during the same period. The spherical equivalent and axial length was recorded at baseline and the sixth month of treatment. The efficacy was evaluated by the change of the spherical equivalent and axial length. Adverse events were also recorded. RESULTS: The average spherical equivalent and axial length at baseline were not statistically significant between the atropine group (-1.64±0.80 D, 24.13±0.76 mm) and the control group (-1.59±0.94 D, 24.06±0.77 mm, P>0.05). After 6mo, there was significantly difference in the spherical equivalent progression between the atropine and the control group (-0.27±0.33 vs -0.60±0.35 D, P<0.001), with a relative reduction of 55.0% in myopia progression. The increase in axial elongation in the atropine group was significantly less than control group (0.19±0.14 vs 0.26±0.14 mm, P<0.001), with a relative reduction of 26.9% in axial length. The 84.4% and 38.4% of the eyes progressed by less than 0.50 D and remained stable in the atropine group, compared with 51.7% and 4.2% in the control group. No adverse events were observed. CONCLUSION: Atropine sulphate eye gel 0.01% can slow down myopia progression and axial elongation in children with a 6-month treatment. |
| first_indexed | 2024-12-12T07:19:38Z |
| format | Article |
| id | doaj.art-5fc32e6e7b1c49759c140dfdd0fd6f3b |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-12-12T07:19:38Z |
| publishDate | 2022-07-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-5fc32e6e7b1c49759c140dfdd0fd6f3b2022-12-22T00:33:24ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982022-07-011571122112710.18240/ijo.2022.07.1220220712Short-term effect of 0.01% atropine sulphate eye gel on myopia progression in childrenShi-Yin Pan0Yang-Zheng Wang1Jun Li2Xue-Hui Zhang3Jin Wang4Xiu-Ping Zhu5Xiang-Hua Xiao6Jun-Tian Liu7Xiang-Hua Xiao. Research for Ophthalmology Diseases of Shaanxi Province, Xi'an First Hospital; Shaanxi Key Laboratory of Ophthalmology, Shaanxi institute of Ophthalmology, Xi'an 710002, Shaanxi Province, China. xianghuaxiao@yeah.net. Jun-Tian Liu. Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an 710061, Shaanxi Province, China. ljt@mail.xjtu.edu.cnShaanxi Provincial Clinical Research Center for Ophthalmology, Xi'an First Hospital, Xi'an 710002, Shaanxi Province, China; Shaanxi Key Laboratory of Ophthalmology, Shaanxi Institute of Ophthalmology, Xi'an 710002, Shaanxi Province, ChinaShaanxi Provincial Clinical Research Center for Ophthalmology, Xi'an First Hospital, Xi'an 710002, Shaanxi Province, China; Shaanxi Key Laboratory of Ophthalmology, Shaanxi Institute of Ophthalmology, Xi'an 710002, Shaanxi Province, ChinaShaanxi Provincial Clinical Research Center for Ophthalmology, Xi'an First Hospital, Xi'an 710002, Shaanxi Province, ChinaShaanxi Provincial Clinical Research Center for Ophthalmology, Xi'an First Hospital, Xi'an 710002, Shaanxi Province, ChinaShaanxi Provincial Clinical Research Center for Ophthalmology, Xi'an First Hospital, Xi'an 710002, Shaanxi Province, China; Shaanxi Key Laboratory of Ophthalmology, Shaanxi Institute of Ophthalmology, Xi'an 710002, Shaanxi Province, ChinaShaanxi Provincial Clinical Research Center for Ophthalmology, Xi'an First Hospital, Xi'an 710002, Shaanxi Province, China; Shaanxi Key Laboratory of Ophthalmology, Shaanxi Institute of Ophthalmology, Xi'an 710002, Shaanxi Province, ChinaDepartment of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an 710061, Shaanxi Pronvince, ChinaAIM: To investigate the effect of 0.01% atropine sulphate eye gel on myopia progression and axial elongation in a 6-month treatment in children. METHODS: Totally 185 children aged 6-12y with binocular myopia of 3.0 D or less in both eyes were enrolled in this prospective cohort study. The atropine group (n=125) received one drop of 0.01% atropine sulphate eye gel in each eye before bedtime daily. The control group included 60 matched children without drug intervention during the same period. The spherical equivalent and axial length was recorded at baseline and the sixth month of treatment. The efficacy was evaluated by the change of the spherical equivalent and axial length. Adverse events were also recorded. RESULTS: The average spherical equivalent and axial length at baseline were not statistically significant between the atropine group (-1.64±0.80 D, 24.13±0.76 mm) and the control group (-1.59±0.94 D, 24.06±0.77 mm, P>0.05). After 6mo, there was significantly difference in the spherical equivalent progression between the atropine and the control group (-0.27±0.33 vs -0.60±0.35 D, P<0.001), with a relative reduction of 55.0% in myopia progression. The increase in axial elongation in the atropine group was significantly less than control group (0.19±0.14 vs 0.26±0.14 mm, P<0.001), with a relative reduction of 26.9% in axial length. The 84.4% and 38.4% of the eyes progressed by less than 0.50 D and remained stable in the atropine group, compared with 51.7% and 4.2% in the control group. No adverse events were observed. CONCLUSION: Atropine sulphate eye gel 0.01% can slow down myopia progression and axial elongation in children with a 6-month treatment.http://ies.ijo.cn/en_publish/2022/7/20220712.pdfatropine sulphate eye gelmyopiaspherical equivalentaxial length |
| spellingShingle | Shi-Yin Pan Yang-Zheng Wang Jun Li Xue-Hui Zhang Jin Wang Xiu-Ping Zhu Xiang-Hua Xiao Jun-Tian Liu Short-term effect of 0.01% atropine sulphate eye gel on myopia progression in children International Journal of Ophthalmology atropine sulphate eye gel myopia spherical equivalent axial length |
| title | Short-term effect of 0.01% atropine sulphate eye gel on myopia progression in children |
| title_full | Short-term effect of 0.01% atropine sulphate eye gel on myopia progression in children |
| title_fullStr | Short-term effect of 0.01% atropine sulphate eye gel on myopia progression in children |
| title_full_unstemmed | Short-term effect of 0.01% atropine sulphate eye gel on myopia progression in children |
| title_short | Short-term effect of 0.01% atropine sulphate eye gel on myopia progression in children |
| title_sort | short term effect of 0 01 atropine sulphate eye gel on myopia progression in children |
| topic | atropine sulphate eye gel myopia spherical equivalent axial length |
| url | http://ies.ijo.cn/en_publish/2022/7/20220712.pdf |
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