Dorsal clock neurons in Drosophila sculpt locomotor outputs but are dispensable for circadian activity rhythms
Summary: The circadian system is comprised three components: a network of core clock cells in the brain that keeps time, input pathways that entrain clock cells to the environment, and output pathways that use this information to ensure appropriate timing of physiological and behavioral processes th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S258900422100969X |
| _version_ | 1818719334174818304 |
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| author | Ella A. Nettnin Thomas R. Sallese Anita Nasseri Sumit Saurabh Daniel J. Cavanaugh |
| author_facet | Ella A. Nettnin Thomas R. Sallese Anita Nasseri Sumit Saurabh Daniel J. Cavanaugh |
| author_sort | Ella A. Nettnin |
| collection | DOAJ |
| description | Summary: The circadian system is comprised three components: a network of core clock cells in the brain that keeps time, input pathways that entrain clock cells to the environment, and output pathways that use this information to ensure appropriate timing of physiological and behavioral processes throughout the day. Core clock cells can be divided into molecularly distinct populations that likely make unique functional contributions. Here we clarify the role of the dorsal neuron 1 (DN1) population of clock neurons in the transmission of circadian information by the Drosophila core clock network. Using an intersectional genetic approach that allowed us to selectively and comprehensively target DN1 cells, we show that suppressing DN1 neuronal activity alters the magnitude of daily activity and sleep without affecting overt rhythmicity. This suggests that DN1 cells are dispensable for both the generation of circadian information and the propagation of this information across output circuits. |
| first_indexed | 2024-12-17T20:05:17Z |
| format | Article |
| id | doaj.art-5fc4b5c7debf48ada86c4c6bcaf8e6d5 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-17T20:05:17Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-5fc4b5c7debf48ada86c4c6bcaf8e6d52022-12-21T21:34:20ZengElsevieriScience2589-00422021-09-01249103001Dorsal clock neurons in Drosophila sculpt locomotor outputs but are dispensable for circadian activity rhythmsElla A. Nettnin0Thomas R. Sallese1Anita Nasseri2Sumit Saurabh3Daniel J. Cavanaugh4Department of Biology, Loyola University Chicago, Chicago IL 60660, USADepartment of Biology, Loyola University Chicago, Chicago IL 60660, USADepartment of Biology, Loyola University Chicago, Chicago IL 60660, USADepartment of Biology, Loyola University Chicago, Chicago IL 60660, USADepartment of Biology, Loyola University Chicago, Chicago IL 60660, USA; Corresponding authorSummary: The circadian system is comprised three components: a network of core clock cells in the brain that keeps time, input pathways that entrain clock cells to the environment, and output pathways that use this information to ensure appropriate timing of physiological and behavioral processes throughout the day. Core clock cells can be divided into molecularly distinct populations that likely make unique functional contributions. Here we clarify the role of the dorsal neuron 1 (DN1) population of clock neurons in the transmission of circadian information by the Drosophila core clock network. Using an intersectional genetic approach that allowed us to selectively and comprehensively target DN1 cells, we show that suppressing DN1 neuronal activity alters the magnitude of daily activity and sleep without affecting overt rhythmicity. This suggests that DN1 cells are dispensable for both the generation of circadian information and the propagation of this information across output circuits.http://www.sciencedirect.com/science/article/pii/S258900422100969XBiological sciencesNeuroscienceBehavioral neuroscienceSensory neuroscience |
| spellingShingle | Ella A. Nettnin Thomas R. Sallese Anita Nasseri Sumit Saurabh Daniel J. Cavanaugh Dorsal clock neurons in Drosophila sculpt locomotor outputs but are dispensable for circadian activity rhythms iScience Biological sciences Neuroscience Behavioral neuroscience Sensory neuroscience |
| title | Dorsal clock neurons in Drosophila sculpt locomotor outputs but are dispensable for circadian activity rhythms |
| title_full | Dorsal clock neurons in Drosophila sculpt locomotor outputs but are dispensable for circadian activity rhythms |
| title_fullStr | Dorsal clock neurons in Drosophila sculpt locomotor outputs but are dispensable for circadian activity rhythms |
| title_full_unstemmed | Dorsal clock neurons in Drosophila sculpt locomotor outputs but are dispensable for circadian activity rhythms |
| title_short | Dorsal clock neurons in Drosophila sculpt locomotor outputs but are dispensable for circadian activity rhythms |
| title_sort | dorsal clock neurons in drosophila sculpt locomotor outputs but are dispensable for circadian activity rhythms |
| topic | Biological sciences Neuroscience Behavioral neuroscience Sensory neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S258900422100969X |
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