Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism
Histone acetylations are important epigenetic marks for transcriptional activation and respond to metabolic changes. Here the authors develop a lifespan screen and show that inactivation of the histone deacetylase complex activates longevity and protects against stress via trehalose metabolism.
Bibliographic Details
| Main Authors: |
Ruofan Yu,
Xiaohua Cao,
Luyang Sun,
Jun-yi Zhu,
Brian M Wasko,
Wei Liu,
Emeline Crutcher,
Haiying Liu,
Myeong Chan Jo,
Lidong Qin,
Matt Kaeberlein,
Zhe Han,
Weiwei Dang |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2021-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-22257-2
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