Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism

Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism

Histone acetylations are important epigenetic marks for transcriptional activation and respond to metabolic changes. Here the authors develop a lifespan screen and show that inactivation of the histone deacetylase complex activates longevity and protects against stress via trehalose metabolism.

Bibliographic Details
Main Authors: Ruofan Yu, Xiaohua Cao, Luyang Sun, Jun-yi Zhu, Brian M Wasko, Wei Liu, Emeline Crutcher, Haiying Liu, Myeong Chan Jo, Lidong Qin, Matt Kaeberlein, Zhe Han, Weiwei Dang
Format: Article
Language:English
Published: Nature Portfolio 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22257-2

Internet

https://doi.org/10.1038/s41467-021-22257-2

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