No evidence for widespread positive selection on double substitutions within codons in primates and yeasts
Nucleotide substitutions in protein-coding genes can be divided into synonymous (S) and non-synonymous (N) ones that alter amino acids (including nonsense mutations causing stop codons). The S substitutions are expected to have little effect on function. The N substitutions almost always are affecte...
Main Authors: | Frida Belinky, Anastassia Bykova, Vyacheslav Yurchenko, Igor B. Rogozin |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-09-01
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Series: | Frontiers in Genetics |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.991249/full |
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