High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center
The polymerase and histidinol phosphatase (PHP) domain in the DNA polymerase DnaE1 is essential for mycobacterial high-fidelity DNA replication. Here, the authors determine the DnaE1 crystal structure, which reveals the PHP-exonuclease mechanism that can be exploited for antibiotic development.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00886-w |
| _version_ | 1818343389991534592 |
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| author | Soledad Baños-Mateos Anne-Marie M. van Roon Ulla F. Lang Sarah L. Maslen J. Mark Skehel Meindert H. Lamers |
| author_facet | Soledad Baños-Mateos Anne-Marie M. van Roon Ulla F. Lang Sarah L. Maslen J. Mark Skehel Meindert H. Lamers |
| author_sort | Soledad Baños-Mateos |
| collection | DOAJ |
| description | The polymerase and histidinol phosphatase (PHP) domain in the DNA polymerase DnaE1 is essential for mycobacterial high-fidelity DNA replication. Here, the authors determine the DnaE1 crystal structure, which reveals the PHP-exonuclease mechanism that can be exploited for antibiotic development. |
| first_indexed | 2024-12-13T16:29:49Z |
| format | Article |
| id | doaj.art-5fc944f0ddb6405aa8447da27bcce74f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:29:49Z |
| publishDate | 2017-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-5fc944f0ddb6405aa8447da27bcce74f2022-12-21T23:38:32ZengNature PortfolioNature Communications2041-17232017-10-018111010.1038/s41467-017-00886-wHigh-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc centerSoledad Baños-Mateos0Anne-Marie M. van Roon1Ulla F. Lang2Sarah L. Maslen3J. Mark Skehel4Meindert H. Lamers5MRC Laboratory of Molecular BiologyMRC Laboratory of Molecular BiologyMRC Laboratory of Molecular BiologyMRC Laboratory of Molecular BiologyMRC Laboratory of Molecular BiologyMRC Laboratory of Molecular BiologyThe polymerase and histidinol phosphatase (PHP) domain in the DNA polymerase DnaE1 is essential for mycobacterial high-fidelity DNA replication. Here, the authors determine the DnaE1 crystal structure, which reveals the PHP-exonuclease mechanism that can be exploited for antibiotic development.https://doi.org/10.1038/s41467-017-00886-w |
| spellingShingle | Soledad Baños-Mateos Anne-Marie M. van Roon Ulla F. Lang Sarah L. Maslen J. Mark Skehel Meindert H. Lamers High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center Nature Communications |
| title | High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center |
| title_full | High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center |
| title_fullStr | High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center |
| title_full_unstemmed | High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center |
| title_short | High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center |
| title_sort | high fidelity dna replication in mycobacterium tuberculosis relies on a trinuclear zinc center |
| url | https://doi.org/10.1038/s41467-017-00886-w |
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