The Robust Restriction of Zika Virus by Type-I Interferon in A549 Cells Varies by Viral Lineage and Is Not Determined by IFITM3

The Robust Restriction of Zika Virus by Type-I Interferon in A549 Cells Varies by Viral Lineage and Is Not Determined by IFITM3

Type-I interferon (IFN-I) is a major antiviral host response but its impact on Zika virus (ZIKV) replication is not well defined, particularly as it relates to different circulating strains. Interferon stimulated genes (ISGs) that inhibit ZIKV, such as IFITM3, have been identified largely using over...

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Bibliographic Details
Main Authors: Theodore A. Gobillot, Daryl Humes, Amit Sharma, Caroline Kikawa, Julie Overbaugh
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Viruses
Subjects:
Zika virus
IFITM3
type-I interferon
interferon-stimulated genes
Online Access:https://www.mdpi.com/1999-4915/12/5/503

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