Differential diagnosis of hypercalcemia in a patient with CKD G5D
Patients with chronic kidney disease are characterized by the development of mineral disorders due to a decrease in the number of functioning nephrons. These changes manifest by the development of secondary hyperparathyroidism (the overproduction of intact parathyroid hormone (PTH) associated with t...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2022-02-01
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| Series: | Ожирение и метаболизм |
| Subjects: | |
| Online Access: | https://www.omet-endojournals.ru/jour/article/view/12742 |
| _version_ | 1797204602520600576 |
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| author | A. K. Eremkina A. M. Gorbacheva D. V. Lisina A. A. Povaliaeva E. A. Pigarova N. G. Mokrysheva |
| author_facet | A. K. Eremkina A. M. Gorbacheva D. V. Lisina A. A. Povaliaeva E. A. Pigarova N. G. Mokrysheva |
| author_sort | A. K. Eremkina |
| collection | DOAJ |
| description | Patients with chronic kidney disease are characterized by the development of mineral disorders due to a decrease in the number of functioning nephrons. These changes manifest by the development of secondary hyperparathyroidism (the overproduction of intact parathyroid hormone (PTH) associated with the serum hypocalcemia, hyperphosphatemia), dysfunctional vitamin D metabolism, bone mineralization and also extraosseous calcifications. Decreased serum PTH levels associated with hypercalcemia are suspicious for adynamic bone disease, but at the same time requires an extended differential diagnostic search (e.g. metastatic processes). One of the rare causes of hypercalcemia is a defect in 24-hydroxylase (CYP24A1). We present a case of a patient on hemodialysis with atypical secondary hyperparathyroidism and an established CYP24A1 defect. |
| first_indexed | 2024-03-08T09:13:11Z |
| format | Article |
| id | doaj.art-5fcae138d39143a99cba56ea64d19248 |
| institution | Directory Open Access Journal |
| issn | 2071-8713 2306-5524 |
| language | English |
| last_indexed | 2024-04-24T08:37:50Z |
| publishDate | 2022-02-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Ожирение и метаболизм |
| spelling | doaj.art-5fcae138d39143a99cba56ea64d192482024-04-16T16:16:13ZengEndocrinology Research CentreОжирение и метаболизм2071-87132306-55242022-02-0118442543110.14341/omet1274210895Differential diagnosis of hypercalcemia in a patient with CKD G5DA. K. Eremkina0A. M. Gorbacheva1D. V. Lisina2A. A. Povaliaeva3E. A. Pigarova4N. G. Mokrysheva5Endocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentrePatients with chronic kidney disease are characterized by the development of mineral disorders due to a decrease in the number of functioning nephrons. These changes manifest by the development of secondary hyperparathyroidism (the overproduction of intact parathyroid hormone (PTH) associated with the serum hypocalcemia, hyperphosphatemia), dysfunctional vitamin D metabolism, bone mineralization and also extraosseous calcifications. Decreased serum PTH levels associated with hypercalcemia are suspicious for adynamic bone disease, but at the same time requires an extended differential diagnostic search (e.g. metastatic processes). One of the rare causes of hypercalcemia is a defect in 24-hydroxylase (CYP24A1). We present a case of a patient on hemodialysis with atypical secondary hyperparathyroidism and an established CYP24A1 defect.https://www.omet-endojournals.ru/jour/article/view/12742hypercalcemiasecondary hyperparathyroidismrenal dialysisvitamin d 24-hydroxylaseckd-mbd |
| spellingShingle | A. K. Eremkina A. M. Gorbacheva D. V. Lisina A. A. Povaliaeva E. A. Pigarova N. G. Mokrysheva Differential diagnosis of hypercalcemia in a patient with CKD G5D Ожирение и метаболизм hypercalcemia secondary hyperparathyroidism renal dialysis vitamin d 24-hydroxylase ckd-mbd |
| title | Differential diagnosis of hypercalcemia in a patient with CKD G5D |
| title_full | Differential diagnosis of hypercalcemia in a patient with CKD G5D |
| title_fullStr | Differential diagnosis of hypercalcemia in a patient with CKD G5D |
| title_full_unstemmed | Differential diagnosis of hypercalcemia in a patient with CKD G5D |
| title_short | Differential diagnosis of hypercalcemia in a patient with CKD G5D |
| title_sort | differential diagnosis of hypercalcemia in a patient with ckd g5d |
| topic | hypercalcemia secondary hyperparathyroidism renal dialysis vitamin d 24-hydroxylase ckd-mbd |
| url | https://www.omet-endojournals.ru/jour/article/view/12742 |
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