Phosphorylation Alters the Properties of Pol η: Implications for Translesion Synthesis

Phosphorylation Alters the Properties of Pol η: Implications for Translesion Synthesis

Summary: There are significant ambiguities regarding how DNA polymerase η is recruited to DNA lesion sites in stressed cells while avoiding normal replication forks in non-stressed cells. Even less is known about the mechanisms responsible for Pol η-induced mutations in cancer genomes. We show that...

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Bibliographic Details
Main Authors: Chandana Peddu, Sufang Zhang, Hong Zhao, Agnes Wong, Ernest Y.C. Lee, Marietta Y.W.T. Lee, Zhongtao Zhang
Format: Article
Language:English
Published: Elsevier 2018-08-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S258900421830097X

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