Evaluation of Chronic Physical and Psychological Stress Induction on Cardiac Ischemia / Reperfusion Injuries in Isolated Male Rat Heart: The Role of Sympathetic Nervous System
Exposure to stress leads to physiological changes called “stress response” which are the result of the changes in the adrenomedullary hormone system, hypothalamus-pituitary-adrenal (HPA) and sympathetic nervous system (SNS) activity. In the present study, the effects of chronic physical and psycholo...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2015-10-01
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| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/4273 |
| _version_ | 1818055366967033856 |
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| author | Kamran Rakhshan Alireza Imani Mahdieh Faghihi Fatemeh Nabavizadeh Masoumeh Golnazari SeyedMorteza Karimian |
| author_facet | Kamran Rakhshan Alireza Imani Mahdieh Faghihi Fatemeh Nabavizadeh Masoumeh Golnazari SeyedMorteza Karimian |
| author_sort | Kamran Rakhshan |
| collection | DOAJ |
| description | Exposure to stress leads to physiological changes called “stress response” which are the result of the changes in the adrenomedullary hormone system, hypothalamus-pituitary-adrenal (HPA) and sympathetic nervous system (SNS) activity. In the present study, the effects of chronic physical and psychological stress and also the role of sympathetic system effects in stress on ischemia/reperfusion (I/R) injuries have been= studied in isolated rat heart. Rat heart was isolated and subjected to 30 min regional ischemia and 120 min reperfusion. The daily stress was induced for one week prior to I/R induction. Sympathectomy was done chemically by injection of hydroxyl-dopamine prior to stress induction. There were no significant changes in heart rate and Coronary Flow between groups. Left ventricular developed pressure (LVDP) and rate product pressure (RPP) in both physical and psychological stress groups decreased significantly compared to those in control group (P<0.05), but there was no significant difference betwe n physical and psychological stress groups. Infarct size significantly increased in both physical and psychological stress groups and control group (P<0.05. Sympathectomy before induction of stress led to the elimination of the deleterious effects of stress as compared with stress groups (P<0.05). These results show that induction of chronic physical and psychological stress prior to ischemia/reperfusion causes enhancement of myocardial injuries and it seems that increased sympathetic activity in response to stress is responsible for these adverse effects of stress on ischemic/reperfused heart. |
| first_indexed | 2024-12-10T12:11:49Z |
| format | Article |
| id | doaj.art-5fcaeee946d849659915fc39d6008647 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-10T12:11:49Z |
| publishDate | 2015-10-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-5fcaeee946d849659915fc39d60086472022-12-22T01:49:20ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942015-10-015384249Evaluation of Chronic Physical and Psychological Stress Induction on Cardiac Ischemia / Reperfusion Injuries in Isolated Male Rat Heart: The Role of Sympathetic Nervous SystemKamran Rakhshan0Alireza Imani1Mahdieh Faghihi2Fatemeh Nabavizadeh3Masoumeh Golnazari4SeyedMorteza Karimian5Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Physiology, Occupational Sleep Research Center Tehran, Tehran, Iran.Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Islamic Azad University, Hamadan Branch, Hamadan, Iran.Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Exposure to stress leads to physiological changes called “stress response” which are the result of the changes in the adrenomedullary hormone system, hypothalamus-pituitary-adrenal (HPA) and sympathetic nervous system (SNS) activity. In the present study, the effects of chronic physical and psychological stress and also the role of sympathetic system effects in stress on ischemia/reperfusion (I/R) injuries have been= studied in isolated rat heart. Rat heart was isolated and subjected to 30 min regional ischemia and 120 min reperfusion. The daily stress was induced for one week prior to I/R induction. Sympathectomy was done chemically by injection of hydroxyl-dopamine prior to stress induction. There were no significant changes in heart rate and Coronary Flow between groups. Left ventricular developed pressure (LVDP) and rate product pressure (RPP) in both physical and psychological stress groups decreased significantly compared to those in control group (P<0.05), but there was no significant difference betwe n physical and psychological stress groups. Infarct size significantly increased in both physical and psychological stress groups and control group (P<0.05. Sympathectomy before induction of stress led to the elimination of the deleterious effects of stress as compared with stress groups (P<0.05). These results show that induction of chronic physical and psychological stress prior to ischemia/reperfusion causes enhancement of myocardial injuries and it seems that increased sympathetic activity in response to stress is responsible for these adverse effects of stress on ischemic/reperfused heart.https://acta.tums.ac.ir/index.php/acta/article/view/4273Ischemia/ReperfusionPhysical stressPsychological stressChemical sympathectomyInfarcted size |
| spellingShingle | Kamran Rakhshan Alireza Imani Mahdieh Faghihi Fatemeh Nabavizadeh Masoumeh Golnazari SeyedMorteza Karimian Evaluation of Chronic Physical and Psychological Stress Induction on Cardiac Ischemia / Reperfusion Injuries in Isolated Male Rat Heart: The Role of Sympathetic Nervous System Acta Medica Iranica Ischemia/Reperfusion Physical stress Psychological stress Chemical sympathectomy Infarcted size |
| title | Evaluation of Chronic Physical and Psychological Stress Induction on Cardiac Ischemia / Reperfusion Injuries in Isolated Male Rat Heart: The Role of Sympathetic Nervous System |
| title_full | Evaluation of Chronic Physical and Psychological Stress Induction on Cardiac Ischemia / Reperfusion Injuries in Isolated Male Rat Heart: The Role of Sympathetic Nervous System |
| title_fullStr | Evaluation of Chronic Physical and Psychological Stress Induction on Cardiac Ischemia / Reperfusion Injuries in Isolated Male Rat Heart: The Role of Sympathetic Nervous System |
| title_full_unstemmed | Evaluation of Chronic Physical and Psychological Stress Induction on Cardiac Ischemia / Reperfusion Injuries in Isolated Male Rat Heart: The Role of Sympathetic Nervous System |
| title_short | Evaluation of Chronic Physical and Psychological Stress Induction on Cardiac Ischemia / Reperfusion Injuries in Isolated Male Rat Heart: The Role of Sympathetic Nervous System |
| title_sort | evaluation of chronic physical and psychological stress induction on cardiac ischemia reperfusion injuries in isolated male rat heart the role of sympathetic nervous system |
| topic | Ischemia/Reperfusion Physical stress Psychological stress Chemical sympathectomy Infarcted size |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/4273 |
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