Identification of Renieramycin A as an Antileishmanial Substance in a Marine Sponge Neopetrosia sp.

Identification of Renieramycin A as an Antileishmanial Substance in a Marine Sponge Neopetrosia sp.

Abstract: The newly developed assay system using recombinant Leishmania amazonensis expressing enhanced green fluorescent protein (La/egfp) has been applied to the screening of Japanese marine sponges for antileishmanial activity. Bioassay-guided fractionation of an active sponge Neopetrosia sp. aff...

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Bibliographic Details
Main Authors: Yoichi Nakao, Takeru Shiroiwa, Shigeki Matsunaga, Shuhei Murayama, Yasuyuki Goto, Yoshitsugu Matsumoto, Nobuhiro Fusetani
Format: Article
Language:English
Published: MDPI AG 2004-05-01
Series:Marine Drugs
Subjects:
leishmaniasis
marine sponge
renieramycin A
Online Access:http://www.mdpi.com/1660-3397/2/2/55/
Description
Summary:Abstract: The newly developed assay system using recombinant Leishmania amazonensis expressing enhanced green fluorescent protein (La/egfp) has been applied to the screening of Japanese marine sponges for antileishmanial activity. Bioassay-guided fractionation of an active sponge Neopetrosia sp. afforded an active compound which was identified as renieramycin A by spectroscopic analysis. It inhibited La/egfp with an IC50 value of 0.2 μg/mL.
ISSN:1660-3397

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