Synthesis and Physiological Remodeling of CD34 Cells in the Skin following the Reversal of Fibrosis through Intensive Treatment for Lower Limb Lymphedema: A Case Report
A novel type of cell underwent identification between 2005 and 2008 and was denominated the “telocyte” in 2010. In 2012, transmission electron microscopy revealed the presence of telocytes in the dermis. The aim of the present study was to report important changes in immunostained CD34 cells followi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Dermatopathology |
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| Online Access: | https://www.mdpi.com/2296-3529/10/1/16 |
| _version_ | 1827750301684203520 |
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| author | Jose Maria Pereira de Godoy Ana Carolina Pereira de Godoy Maria de Fatima Guerreiro Godoy Dalisio de Santi Neto |
| author_facet | Jose Maria Pereira de Godoy Ana Carolina Pereira de Godoy Maria de Fatima Guerreiro Godoy Dalisio de Santi Neto |
| author_sort | Jose Maria Pereira de Godoy |
| collection | DOAJ |
| description | A novel type of cell underwent identification between 2005 and 2008 and was denominated the “telocyte” in 2010. In 2012, transmission electron microscopy revealed the presence of telocytes in the dermis. The aim of the present study was to report important changes in immunostained CD34 cells following the treatment of lower limb lymphedema using a specific lymphatic therapy technique. A clinical trial involving the evaluation of changes in immunostained CD34 cells in the epidermis and dermis (10 randomly selected histological fields) of a patient before and after intensive treatment for clinical stage II lymphedema was conducted using the Godoy Method, which was adapted to the treatment of skin fibrosis. The evaluation involved the use of the Weibel multi-point morphometric method. Comparisons were performed using the <i>t</i>-test with a 95% significance level. An important increase in CD34 cells was found with redistribution occurring following treatment. The treatment of primary lymphedema of the lower limbs resulted in the clinical reversal of fibrosis and an increase in the number of immunomarked CD34 cells. |
| first_indexed | 2024-03-11T06:41:46Z |
| format | Article |
| id | doaj.art-5fccf3e35af2424d8c2d9e6140115d2e |
| institution | Directory Open Access Journal |
| issn | 2296-3529 |
| language | English |
| last_indexed | 2024-03-11T06:41:46Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dermatopathology |
| spelling | doaj.art-5fccf3e35af2424d8c2d9e6140115d2e2023-11-17T10:32:50ZengMDPI AGDermatopathology2296-35292023-03-0110110411110.3390/dermatopathology10010016Synthesis and Physiological Remodeling of CD34 Cells in the Skin following the Reversal of Fibrosis through Intensive Treatment for Lower Limb Lymphedema: A Case ReportJose Maria Pereira de Godoy0Ana Carolina Pereira de Godoy1Maria de Fatima Guerreiro Godoy2Dalisio de Santi Neto3Department of the Medicine School, São José do Rio Preto (FAMERP), CNPq (National Council for Research and Development), Sao Jose do Rio Preto 15090-000, BrazilResearch Group of the Clínica Godoy, Intensive Surgery Pediatric Cardiac, Hospital da Criança e Maternidade—HCM, Medicine School of Sao Jose do Rio Preto (FAMERP), Sao Jose do Rio Preto 15090-000, BrazilResearch Group in the Clínica Godoy, Medicine School of São José do Rio Preto (FAMERP), Sao Jose do Rio Preto 15090-000, BrazilHospital de Base, Medicine School of São José do Rio Preto (FAMERP), Sao Jose do Rio Preto 15090-000, BrazilA novel type of cell underwent identification between 2005 and 2008 and was denominated the “telocyte” in 2010. In 2012, transmission electron microscopy revealed the presence of telocytes in the dermis. The aim of the present study was to report important changes in immunostained CD34 cells following the treatment of lower limb lymphedema using a specific lymphatic therapy technique. A clinical trial involving the evaluation of changes in immunostained CD34 cells in the epidermis and dermis (10 randomly selected histological fields) of a patient before and after intensive treatment for clinical stage II lymphedema was conducted using the Godoy Method, which was adapted to the treatment of skin fibrosis. The evaluation involved the use of the Weibel multi-point morphometric method. Comparisons were performed using the <i>t</i>-test with a 95% significance level. An important increase in CD34 cells was found with redistribution occurring following treatment. The treatment of primary lymphedema of the lower limbs resulted in the clinical reversal of fibrosis and an increase in the number of immunomarked CD34 cells.https://www.mdpi.com/2296-3529/10/1/16skinCD34telocytestreatmentfibrosis |
| spellingShingle | Jose Maria Pereira de Godoy Ana Carolina Pereira de Godoy Maria de Fatima Guerreiro Godoy Dalisio de Santi Neto Synthesis and Physiological Remodeling of CD34 Cells in the Skin following the Reversal of Fibrosis through Intensive Treatment for Lower Limb Lymphedema: A Case Report Dermatopathology skin CD34 telocytes treatment fibrosis |
| title | Synthesis and Physiological Remodeling of CD34 Cells in the Skin following the Reversal of Fibrosis through Intensive Treatment for Lower Limb Lymphedema: A Case Report |
| title_full | Synthesis and Physiological Remodeling of CD34 Cells in the Skin following the Reversal of Fibrosis through Intensive Treatment for Lower Limb Lymphedema: A Case Report |
| title_fullStr | Synthesis and Physiological Remodeling of CD34 Cells in the Skin following the Reversal of Fibrosis through Intensive Treatment for Lower Limb Lymphedema: A Case Report |
| title_full_unstemmed | Synthesis and Physiological Remodeling of CD34 Cells in the Skin following the Reversal of Fibrosis through Intensive Treatment for Lower Limb Lymphedema: A Case Report |
| title_short | Synthesis and Physiological Remodeling of CD34 Cells in the Skin following the Reversal of Fibrosis through Intensive Treatment for Lower Limb Lymphedema: A Case Report |
| title_sort | synthesis and physiological remodeling of cd34 cells in the skin following the reversal of fibrosis through intensive treatment for lower limb lymphedema a case report |
| topic | skin CD34 telocytes treatment fibrosis |
| url | https://www.mdpi.com/2296-3529/10/1/16 |
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