Clinical data warehouses for disease diagnosis: A focus on exosomal MicroRNA biomarkers
Cardiovascular disease (CVD) is a leading cause of mortality worldwide, with an intricate interplay of genetic and environmental factors contributing to disease pathogenesis. MicroRNAs (μRNAs) and long non-coding RNAs (lncRNAs), critical regulators of gene expression, have been implicated in various...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Informatics in Medicine Unlocked |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352914823002368 |
| _version_ | 1827593642910416896 |
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| author | Fionn Ó. Maolmhuaidh Ranul D. Thantilage Denise Burtenshaw Khuram Raja Nhien-An Le-Khac Paul Cahill Robert Forster M-Tahar Kechadi |
| author_facet | Fionn Ó. Maolmhuaidh Ranul D. Thantilage Denise Burtenshaw Khuram Raja Nhien-An Le-Khac Paul Cahill Robert Forster M-Tahar Kechadi |
| author_sort | Fionn Ó. Maolmhuaidh |
| collection | DOAJ |
| description | Cardiovascular disease (CVD) is a leading cause of mortality worldwide, with an intricate interplay of genetic and environmental factors contributing to disease pathogenesis. MicroRNAs (μRNAs) and long non-coding RNAs (lncRNAs), critical regulators of gene expression, have been implicated in various aspects of CVD. This review provides an overview of the roles of specific μRNAs and lncRNAs in cardiovascular health and disease, discussing their potential as biomarkers and therapeutic targets. We also delve into the various techniques, challenges, and future directions for μRNA detection and analysis, highlighting the importance of high-throughput technologies such as microarray experiments and next-generation sequencing. Moreover, the advent of Big Data has necessitated efficient clinical data warehousing, a critical component of μRNA research. We further address the essential data security and privacy considerations when storing and processing sensitive μRNA data. Collectively, this review underscores the significance of μRNAs and lncRNAs in CVD and emphasizes the importance of technological advancements and responsible data management in propelling this research field forward. |
| first_indexed | 2024-03-09T02:14:38Z |
| format | Article |
| id | doaj.art-5fce3e413211413bbd8ed7afc0230614 |
| institution | Directory Open Access Journal |
| issn | 2352-9148 |
| language | English |
| last_indexed | 2024-03-09T02:14:38Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Informatics in Medicine Unlocked |
| spelling | doaj.art-5fce3e413211413bbd8ed7afc02306142023-12-07T05:29:12ZengElsevierInformatics in Medicine Unlocked2352-91482023-01-0143101390Clinical data warehouses for disease diagnosis: A focus on exosomal MicroRNA biomarkersFionn Ó. Maolmhuaidh0Ranul D. Thantilage1Denise Burtenshaw2Khuram Raja3Nhien-An Le-Khac4Paul Cahill5Robert Forster6M-Tahar Kechadi7School of Chemical Science, Dublin City University, DCU Glasnevin Campus, Dublin, 0009, Ireland; Corresponding author.School of Computer Science, University College Dublin, Belfield, Dublin, 0004, Ireland; Insight Centre for Data Analytics, University College Dublin, Belfield, Dublin, 0004, IrelandSchool of Chemical Science, Dublin City University, DCU Glasnevin Campus, Dublin, 0009, IrelandDepartment of Diabetes and Cardiovascular Science, Centre for Health Science, University of the Highlands and Islands, Ness Walk, Inverness, IV3 5SQ, United KingdomSchool of Computer Science, University College Dublin, Belfield, Dublin, 0004, IrelandSchool of Biotechnology, Dublin City University, DCU Glasnevin Campus, Dublin, 0009, IrelandSchool of Chemical Science, Dublin City University, DCU Glasnevin Campus, Dublin, 0009, IrelandSchool of Computer Science, University College Dublin, Belfield, Dublin, 0004, Ireland; Insight Centre for Data Analytics, University College Dublin, Belfield, Dublin, 0004, IrelandCardiovascular disease (CVD) is a leading cause of mortality worldwide, with an intricate interplay of genetic and environmental factors contributing to disease pathogenesis. MicroRNAs (μRNAs) and long non-coding RNAs (lncRNAs), critical regulators of gene expression, have been implicated in various aspects of CVD. This review provides an overview of the roles of specific μRNAs and lncRNAs in cardiovascular health and disease, discussing their potential as biomarkers and therapeutic targets. We also delve into the various techniques, challenges, and future directions for μRNA detection and analysis, highlighting the importance of high-throughput technologies such as microarray experiments and next-generation sequencing. Moreover, the advent of Big Data has necessitated efficient clinical data warehousing, a critical component of μRNA research. We further address the essential data security and privacy considerations when storing and processing sensitive μRNA data. Collectively, this review underscores the significance of μRNAs and lncRNAs in CVD and emphasizes the importance of technological advancements and responsible data management in propelling this research field forward.http://www.sciencedirect.com/science/article/pii/S2352914823002368Cardiovascular diseaseμRNALong non-coding RNAsBiomarkersTherapeutic targetsμRNA detection |
| spellingShingle | Fionn Ó. Maolmhuaidh Ranul D. Thantilage Denise Burtenshaw Khuram Raja Nhien-An Le-Khac Paul Cahill Robert Forster M-Tahar Kechadi Clinical data warehouses for disease diagnosis: A focus on exosomal MicroRNA biomarkers Informatics in Medicine Unlocked Cardiovascular disease μRNA Long non-coding RNAs Biomarkers Therapeutic targets μRNA detection |
| title | Clinical data warehouses for disease diagnosis: A focus on exosomal MicroRNA biomarkers |
| title_full | Clinical data warehouses for disease diagnosis: A focus on exosomal MicroRNA biomarkers |
| title_fullStr | Clinical data warehouses for disease diagnosis: A focus on exosomal MicroRNA biomarkers |
| title_full_unstemmed | Clinical data warehouses for disease diagnosis: A focus on exosomal MicroRNA biomarkers |
| title_short | Clinical data warehouses for disease diagnosis: A focus on exosomal MicroRNA biomarkers |
| title_sort | clinical data warehouses for disease diagnosis a focus on exosomal microrna biomarkers |
| topic | Cardiovascular disease μRNA Long non-coding RNAs Biomarkers Therapeutic targets μRNA detection |
| url | http://www.sciencedirect.com/science/article/pii/S2352914823002368 |
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