CTHRC1 overexpression predicts poor survival and enhances epithelial‐mesenchymal transition in colorectal cancer
Abstract Collagen triple helix repeat containing (CTHRC1), which was identified as a cancer‐related factor, is a promigratory protein involved in multiple processes, including vascular remodeling, antifibrosis, metabolism, bone formation, and cancer. In this study, we aimed to investigate the clinic...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-11-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.1807 |
| _version_ | 1797681443790389248 |
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| author | Shujuan Ni Fei Ren Midie Xu Cong Tan Weiwei Weng Zhaohui Huang Weiqi Sheng Dan Huang |
| author_facet | Shujuan Ni Fei Ren Midie Xu Cong Tan Weiwei Weng Zhaohui Huang Weiqi Sheng Dan Huang |
| author_sort | Shujuan Ni |
| collection | DOAJ |
| description | Abstract Collagen triple helix repeat containing (CTHRC1), which was identified as a cancer‐related factor, is a promigratory protein involved in multiple processes, including vascular remodeling, antifibrosis, metabolism, bone formation, and cancer. In this study, we aimed to investigate the clinical significance and possible role of CTHRC1 in the process of epithelial‐mesenchymal transition (EMT) in colorectal cancer (CRC). Here, we revealed that CTHRC1 mRNA and protein levels are both upregulated in CRC tissues compared with those of paired noncancerous tissues. Moreover, the overexpression of CTHRC1 correlated with poor prognosis in patients with CRC (especially colon cancer). Furthermore, we showed that CTHRC1 induced EMT and promoted cell motility in CRC cells. Importantly, we demonstrated that CTHRC1 promoted EMT by activating transforming growth factor‐β (TGF‐β) signaling, revealing a possible effective therapeutic treatment for patients with CRC. |
| first_indexed | 2024-03-11T23:44:55Z |
| format | Article |
| id | doaj.art-5fcf1a02683a4b6490e462ed3492412b |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-03-11T23:44:55Z |
| publishDate | 2018-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-5fcf1a02683a4b6490e462ed3492412b2023-09-19T11:30:57ZengWileyCancer Medicine2045-76342018-11-017115643565410.1002/cam4.1807CTHRC1 overexpression predicts poor survival and enhances epithelial‐mesenchymal transition in colorectal cancerShujuan Ni0Fei Ren1Midie Xu2Cong Tan3Weiwei Weng4Zhaohui Huang5Weiqi Sheng6Dan Huang7Department of Pathology Fudan University Shanghai Cancer Center Shanghai ChinaDepartment of Pathology Fudan University Shanghai Cancer Center Shanghai ChinaDepartment of Pathology Fudan University Shanghai Cancer Center Shanghai ChinaDepartment of Pathology Fudan University Shanghai Cancer Center Shanghai ChinaDepartment of Pathology Fudan University Shanghai Cancer Center Shanghai ChinaWuxi Cancer Institute Affiliated Hospital of Jiangnan University Wuxi ChinaDepartment of Pathology Fudan University Shanghai Cancer Center Shanghai ChinaDepartment of Pathology Fudan University Shanghai Cancer Center Shanghai ChinaAbstract Collagen triple helix repeat containing (CTHRC1), which was identified as a cancer‐related factor, is a promigratory protein involved in multiple processes, including vascular remodeling, antifibrosis, metabolism, bone formation, and cancer. In this study, we aimed to investigate the clinical significance and possible role of CTHRC1 in the process of epithelial‐mesenchymal transition (EMT) in colorectal cancer (CRC). Here, we revealed that CTHRC1 mRNA and protein levels are both upregulated in CRC tissues compared with those of paired noncancerous tissues. Moreover, the overexpression of CTHRC1 correlated with poor prognosis in patients with CRC (especially colon cancer). Furthermore, we showed that CTHRC1 induced EMT and promoted cell motility in CRC cells. Importantly, we demonstrated that CTHRC1 promoted EMT by activating transforming growth factor‐β (TGF‐β) signaling, revealing a possible effective therapeutic treatment for patients with CRC.https://doi.org/10.1002/cam4.1807colorectal cancerCTHRC1epithelial‐mesenchymal transitionprognosisTGF‐β |
| spellingShingle | Shujuan Ni Fei Ren Midie Xu Cong Tan Weiwei Weng Zhaohui Huang Weiqi Sheng Dan Huang CTHRC1 overexpression predicts poor survival and enhances epithelial‐mesenchymal transition in colorectal cancer Cancer Medicine colorectal cancer CTHRC1 epithelial‐mesenchymal transition prognosis TGF‐β |
| title | CTHRC1 overexpression predicts poor survival and enhances epithelial‐mesenchymal transition in colorectal cancer |
| title_full | CTHRC1 overexpression predicts poor survival and enhances epithelial‐mesenchymal transition in colorectal cancer |
| title_fullStr | CTHRC1 overexpression predicts poor survival and enhances epithelial‐mesenchymal transition in colorectal cancer |
| title_full_unstemmed | CTHRC1 overexpression predicts poor survival and enhances epithelial‐mesenchymal transition in colorectal cancer |
| title_short | CTHRC1 overexpression predicts poor survival and enhances epithelial‐mesenchymal transition in colorectal cancer |
| title_sort | cthrc1 overexpression predicts poor survival and enhances epithelial mesenchymal transition in colorectal cancer |
| topic | colorectal cancer CTHRC1 epithelial‐mesenchymal transition prognosis TGF‐β |
| url | https://doi.org/10.1002/cam4.1807 |
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