Telomere Maintenance and the cGAS-STING Pathway in Cancer

Telomere Maintenance and the cGAS-STING Pathway in Cancer

Cancer cells exhibit the unique characteristics of high proliferation and aberrant DNA damage response, which prevents cancer therapy from effectively eliminating them. The machinery required for telomere maintenance, such as telomerase and the alternative lengthening of telomeres (ALT), enables can...

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Bibliographic Details
Main Authors: Hiroshi Ebata, Tze Mun Loo, Akiko Takahashi
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cells
Subjects:
DNA damage
telomere
cGAS-STING
cancer
ALT
cellular senescence
Online Access:https://www.mdpi.com/2073-4409/11/12/1958

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