Metabolites From the Mangrove-Derived Fungus Cladosporium sp. HNWSW-1
Two new benzoic acids, cladoslide A (1) and cladoslide B (2); one new β-carboline derivative, cladospomine (3); and one new pyridin-2(1H)-one, cladoslide C (4), were isolated from the fermentation cultures of the mangrove-derived fungus Cladosporium sp. HNWSW-1, along with the previously reported N-...
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2021.773703/full |
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| author | Xi Cao Xi Cao Lei Guo Caihong Cai Fandong Kong Jingzhe Yuan Cuijuan Gai Haofu Dai Pei Wang Wenli Mei |
| author_facet | Xi Cao Xi Cao Lei Guo Caihong Cai Fandong Kong Jingzhe Yuan Cuijuan Gai Haofu Dai Pei Wang Wenli Mei |
| author_sort | Xi Cao |
| collection | DOAJ |
| description | Two new benzoic acids, cladoslide A (1) and cladoslide B (2); one new β-carboline derivative, cladospomine (3); and one new pyridin-2(1H)-one, cladoslide C (4), were isolated from the fermentation cultures of the mangrove-derived fungus Cladosporium sp. HNWSW-1, along with the previously reported N-acetyl-β-oxotryptamine (5), (4S,5S,11R)-iso-cladospolide B (6), (4S,5S,11S)-iso-cladospolide B (7), and (4R,5S,11R)-iso-cladospolide B (8). Their structures were elucidated by spectroscopic analysis, Rh2(OCOCF3)4-induced ECD experiments, and Marfey’s method. Compound 1 showed cytotoxicity against the K562 cell line with IC50 values of 13.10 ± 0.08 μM. Moreover, compounds 1 and 5 exhibited inhibitory activity against α-glycosidase with IC50 values of 0.32 ± 0.01 mM and 0.17 ± 0.01 mM, respectively. |
| first_indexed | 2024-12-13T21:18:54Z |
| format | Article |
| id | doaj.art-5fd03cd3c0b54ae795a1751e3f023d58 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-13T21:18:54Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Chemistry |
| spelling | doaj.art-5fd03cd3c0b54ae795a1751e3f023d582022-12-21T23:31:11ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462021-12-01910.3389/fchem.2021.773703773703Metabolites From the Mangrove-Derived Fungus Cladosporium sp. HNWSW-1Xi Cao0Xi Cao1Lei Guo2Caihong Cai3Fandong Kong4Jingzhe Yuan5Cuijuan Gai6Haofu Dai7Pei Wang8Wenli Mei9Hainan Key Laboratory for Research and Development of Natural Products From Li Folk Medicine, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, ChinaJiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Ocean University, Lianyungang, ChinaJiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Ocean University, Lianyungang, ChinaHainan Key Laboratory for Research and Development of Natural Products From Li Folk Medicine, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, ChinaKey Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering, Guangxi University for Nationalities, Nanning, ChinaHainan Key Laboratory for Research and Development of Natural Products From Li Folk Medicine, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, ChinaHainan Key Laboratory for Research and Development of Natural Products From Li Folk Medicine, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, ChinaHainan Key Laboratory for Research and Development of Natural Products From Li Folk Medicine, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, ChinaHainan Key Laboratory for Research and Development of Natural Products From Li Folk Medicine, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, ChinaHainan Key Laboratory for Research and Development of Natural Products From Li Folk Medicine, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, ChinaTwo new benzoic acids, cladoslide A (1) and cladoslide B (2); one new β-carboline derivative, cladospomine (3); and one new pyridin-2(1H)-one, cladoslide C (4), were isolated from the fermentation cultures of the mangrove-derived fungus Cladosporium sp. HNWSW-1, along with the previously reported N-acetyl-β-oxotryptamine (5), (4S,5S,11R)-iso-cladospolide B (6), (4S,5S,11S)-iso-cladospolide B (7), and (4R,5S,11R)-iso-cladospolide B (8). Their structures were elucidated by spectroscopic analysis, Rh2(OCOCF3)4-induced ECD experiments, and Marfey’s method. Compound 1 showed cytotoxicity against the K562 cell line with IC50 values of 13.10 ± 0.08 μM. Moreover, compounds 1 and 5 exhibited inhibitory activity against α-glycosidase with IC50 values of 0.32 ± 0.01 mM and 0.17 ± 0.01 mM, respectively.https://www.frontiersin.org/articles/10.3389/fchem.2021.773703/fullmangrove-derived fungusCladosporium sp.metabolitescytotoxicityα-glycosidase inhibitor |
| spellingShingle | Xi Cao Xi Cao Lei Guo Caihong Cai Fandong Kong Jingzhe Yuan Cuijuan Gai Haofu Dai Pei Wang Wenli Mei Metabolites From the Mangrove-Derived Fungus Cladosporium sp. HNWSW-1 Frontiers in Chemistry mangrove-derived fungus Cladosporium sp. metabolites cytotoxicity α-glycosidase inhibitor |
| title | Metabolites From the Mangrove-Derived Fungus Cladosporium sp. HNWSW-1 |
| title_full | Metabolites From the Mangrove-Derived Fungus Cladosporium sp. HNWSW-1 |
| title_fullStr | Metabolites From the Mangrove-Derived Fungus Cladosporium sp. HNWSW-1 |
| title_full_unstemmed | Metabolites From the Mangrove-Derived Fungus Cladosporium sp. HNWSW-1 |
| title_short | Metabolites From the Mangrove-Derived Fungus Cladosporium sp. HNWSW-1 |
| title_sort | metabolites from the mangrove derived fungus cladosporium sp hnwsw 1 |
| topic | mangrove-derived fungus Cladosporium sp. metabolites cytotoxicity α-glycosidase inhibitor |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2021.773703/full |
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