Combination of methylprednisolone and rosiglitazone promotes recovery of neurological function after spinal cord injury

Methylprednisolone exhibits anti-inflammatory antioxidant properties, and rosiglitazone acts as an anti-inflammatory and antioxidant by activating peroxisome proliferator-activated receptor-γ in the spinal cord. Methylprednisolone and rosiglitazone have been clinically used during the early stages o...

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Main Authors: Xi-gong Li, Xiang-jin Lin, Jun-hua Du, San-zhong Xu, Xian-feng Lou, Zhong Chen
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2016-01-01
Series:Neural Regeneration Research
Subjects:
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=10;spage=1678;epage=1684;aulast=Li
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author Xi-gong Li
Xiang-jin Lin
Jun-hua Du
San-zhong Xu
Xian-feng Lou
Zhong Chen
author_facet Xi-gong Li
Xiang-jin Lin
Jun-hua Du
San-zhong Xu
Xian-feng Lou
Zhong Chen
author_sort Xi-gong Li
collection DOAJ
description Methylprednisolone exhibits anti-inflammatory antioxidant properties, and rosiglitazone acts as an anti-inflammatory and antioxidant by activating peroxisome proliferator-activated receptor-γ in the spinal cord. Methylprednisolone and rosiglitazone have been clinically used during the early stages of secondary spinal cord injury. Because of the complexity and diversity of the inflammatory process after spinal cord injury, a single drug cannot completely inhibit inflammation. Therefore, we assumed that a combination of methylprednisolone and rosiglitazone might promote recovery of neurological function after secondary spinal cord injury. In this study, rats were intraperitoneally injected with methylprednisolone (30 mg/kg) and rosiglitazone (2 mg/kg) at 1 hour after injury, and methylprednisolone (15 mg/kg) at 24 and 48 hours after injury. Rosiglitazone was then administered once every 12 hours for 7 consecutive days. Our results demonstrated that a combined treatment with methylprednisolone and rosiglitazone had a more pronounced effect on attenuation of inflammation and cell apoptosis, as well as increased functional recovery, compared with either single treatment alone, indicating that a combination better promoted recovery of neurological function after injury.
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spelling doaj.art-5fd4d5b8b20b4f9c9f9a8e2e5e57a0072022-12-22T00:08:14ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742016-01-0111101678168410.4103/1673-5374.193250Combination of methylprednisolone and rosiglitazone promotes recovery of neurological function after spinal cord injuryXi-gong LiXiang-jin LinJun-hua DuSan-zhong XuXian-feng LouZhong ChenMethylprednisolone exhibits anti-inflammatory antioxidant properties, and rosiglitazone acts as an anti-inflammatory and antioxidant by activating peroxisome proliferator-activated receptor-γ in the spinal cord. Methylprednisolone and rosiglitazone have been clinically used during the early stages of secondary spinal cord injury. Because of the complexity and diversity of the inflammatory process after spinal cord injury, a single drug cannot completely inhibit inflammation. Therefore, we assumed that a combination of methylprednisolone and rosiglitazone might promote recovery of neurological function after secondary spinal cord injury. In this study, rats were intraperitoneally injected with methylprednisolone (30 mg/kg) and rosiglitazone (2 mg/kg) at 1 hour after injury, and methylprednisolone (15 mg/kg) at 24 and 48 hours after injury. Rosiglitazone was then administered once every 12 hours for 7 consecutive days. Our results demonstrated that a combined treatment with methylprednisolone and rosiglitazone had a more pronounced effect on attenuation of inflammation and cell apoptosis, as well as increased functional recovery, compared with either single treatment alone, indicating that a combination better promoted recovery of neurological function after injury.http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=10;spage=1678;epage=1684;aulast=Linerve regeneration; spinal cord injury; methylprednisolone; rosiglitazone; inflammation; drug therapy; anti-inflammatory agents; functional recovery; neural regeneration
spellingShingle Xi-gong Li
Xiang-jin Lin
Jun-hua Du
San-zhong Xu
Xian-feng Lou
Zhong Chen
Combination of methylprednisolone and rosiglitazone promotes recovery of neurological function after spinal cord injury
Neural Regeneration Research
nerve regeneration; spinal cord injury; methylprednisolone; rosiglitazone; inflammation; drug therapy; anti-inflammatory agents; functional recovery; neural regeneration
title Combination of methylprednisolone and rosiglitazone promotes recovery of neurological function after spinal cord injury
title_full Combination of methylprednisolone and rosiglitazone promotes recovery of neurological function after spinal cord injury
title_fullStr Combination of methylprednisolone and rosiglitazone promotes recovery of neurological function after spinal cord injury
title_full_unstemmed Combination of methylprednisolone and rosiglitazone promotes recovery of neurological function after spinal cord injury
title_short Combination of methylprednisolone and rosiglitazone promotes recovery of neurological function after spinal cord injury
title_sort combination of methylprednisolone and rosiglitazone promotes recovery of neurological function after spinal cord injury
topic nerve regeneration; spinal cord injury; methylprednisolone; rosiglitazone; inflammation; drug therapy; anti-inflammatory agents; functional recovery; neural regeneration
url http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=10;spage=1678;epage=1684;aulast=Li
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AT junhuadu combinationofmethylprednisoloneandrosiglitazonepromotesrecoveryofneurologicalfunctionafterspinalcordinjury
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