Combination of methylprednisolone and rosiglitazone promotes recovery of neurological function after spinal cord injury
Methylprednisolone exhibits anti-inflammatory antioxidant properties, and rosiglitazone acts as an anti-inflammatory and antioxidant by activating peroxisome proliferator-activated receptor-γ in the spinal cord. Methylprednisolone and rosiglitazone have been clinically used during the early stages o...
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Format: | Article |
Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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Series: | Neural Regeneration Research |
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Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=10;spage=1678;epage=1684;aulast=Li |
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author | Xi-gong Li Xiang-jin Lin Jun-hua Du San-zhong Xu Xian-feng Lou Zhong Chen |
author_facet | Xi-gong Li Xiang-jin Lin Jun-hua Du San-zhong Xu Xian-feng Lou Zhong Chen |
author_sort | Xi-gong Li |
collection | DOAJ |
description | Methylprednisolone exhibits anti-inflammatory antioxidant properties, and rosiglitazone acts as an anti-inflammatory and antioxidant by activating peroxisome proliferator-activated receptor-γ in the spinal cord. Methylprednisolone and rosiglitazone have been clinically used during the early stages of secondary spinal cord injury. Because of the complexity and diversity of the inflammatory process after spinal cord injury, a single drug cannot completely inhibit inflammation. Therefore, we assumed that a combination of methylprednisolone and rosiglitazone might promote recovery of neurological function after secondary spinal cord injury. In this study, rats were intraperitoneally injected with methylprednisolone (30 mg/kg) and rosiglitazone (2 mg/kg) at 1 hour after injury, and methylprednisolone (15 mg/kg) at 24 and 48 hours after injury. Rosiglitazone was then administered once every 12 hours for 7 consecutive days. Our results demonstrated that a combined treatment with methylprednisolone and rosiglitazone had a more pronounced effect on attenuation of inflammation and cell apoptosis, as well as increased functional recovery, compared with either single treatment alone, indicating that a combination better promoted recovery of neurological function after injury. |
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issn | 1673-5374 |
language | English |
last_indexed | 2024-12-12T23:21:49Z |
publishDate | 2016-01-01 |
publisher | Wolters Kluwer Medknow Publications |
record_format | Article |
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spelling | doaj.art-5fd4d5b8b20b4f9c9f9a8e2e5e57a0072022-12-22T00:08:14ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742016-01-0111101678168410.4103/1673-5374.193250Combination of methylprednisolone and rosiglitazone promotes recovery of neurological function after spinal cord injuryXi-gong LiXiang-jin LinJun-hua DuSan-zhong XuXian-feng LouZhong ChenMethylprednisolone exhibits anti-inflammatory antioxidant properties, and rosiglitazone acts as an anti-inflammatory and antioxidant by activating peroxisome proliferator-activated receptor-γ in the spinal cord. Methylprednisolone and rosiglitazone have been clinically used during the early stages of secondary spinal cord injury. Because of the complexity and diversity of the inflammatory process after spinal cord injury, a single drug cannot completely inhibit inflammation. Therefore, we assumed that a combination of methylprednisolone and rosiglitazone might promote recovery of neurological function after secondary spinal cord injury. In this study, rats were intraperitoneally injected with methylprednisolone (30 mg/kg) and rosiglitazone (2 mg/kg) at 1 hour after injury, and methylprednisolone (15 mg/kg) at 24 and 48 hours after injury. Rosiglitazone was then administered once every 12 hours for 7 consecutive days. Our results demonstrated that a combined treatment with methylprednisolone and rosiglitazone had a more pronounced effect on attenuation of inflammation and cell apoptosis, as well as increased functional recovery, compared with either single treatment alone, indicating that a combination better promoted recovery of neurological function after injury.http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=10;spage=1678;epage=1684;aulast=Linerve regeneration; spinal cord injury; methylprednisolone; rosiglitazone; inflammation; drug therapy; anti-inflammatory agents; functional recovery; neural regeneration |
spellingShingle | Xi-gong Li Xiang-jin Lin Jun-hua Du San-zhong Xu Xian-feng Lou Zhong Chen Combination of methylprednisolone and rosiglitazone promotes recovery of neurological function after spinal cord injury Neural Regeneration Research nerve regeneration; spinal cord injury; methylprednisolone; rosiglitazone; inflammation; drug therapy; anti-inflammatory agents; functional recovery; neural regeneration |
title | Combination of methylprednisolone and rosiglitazone promotes recovery of neurological function after spinal cord injury |
title_full | Combination of methylprednisolone and rosiglitazone promotes recovery of neurological function after spinal cord injury |
title_fullStr | Combination of methylprednisolone and rosiglitazone promotes recovery of neurological function after spinal cord injury |
title_full_unstemmed | Combination of methylprednisolone and rosiglitazone promotes recovery of neurological function after spinal cord injury |
title_short | Combination of methylprednisolone and rosiglitazone promotes recovery of neurological function after spinal cord injury |
title_sort | combination of methylprednisolone and rosiglitazone promotes recovery of neurological function after spinal cord injury |
topic | nerve regeneration; spinal cord injury; methylprednisolone; rosiglitazone; inflammation; drug therapy; anti-inflammatory agents; functional recovery; neural regeneration |
url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=10;spage=1678;epage=1684;aulast=Li |
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