The relationship between anxiety and serum urotensin-II and S100B levels in patients with essential hypertension (eng)
INTRODUCTION[|]In hypertensive people, some biochemical parameters that are associated with oxidative stress and endothelial functions may play a role in the manifestation of anxiety symptoms, and even in the intensification of clinical symptoms of the disease. The objective of this correlational st...
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| Format: | Article |
| Language: | English |
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ANP Publishing
2021-09-01
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| Series: | Klinik Psikiyatri Dergisi |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=kpd&un=KPD-67044 |
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| author | Aslı Kazğan Sevda Korkmaz Sevler Yildiz Hasan Korkmaz Selda Telo Murad Atmaca |
| author_facet | Aslı Kazğan Sevda Korkmaz Sevler Yildiz Hasan Korkmaz Selda Telo Murad Atmaca |
| author_sort | Aslı Kazğan |
| collection | DOAJ |
| description | INTRODUCTION[|]In hypertensive people, some biochemical parameters that are associated with oxidative stress and endothelial functions may play a role in the manifestation of anxiety symptoms, and even in the intensification of clinical symptoms of the disease. The objective of this correlational study is to examine the association between the severity of anxiety and levels of oxidative stress parameters including Urotensin-II and S100B protein in patients with essential hypertension.[¤]METHODS[|]A total of 153 patients meeting the study criteria who presented to the department of cardiology and received outpatient treatment were included in the study. Sociodemographic and Clinical Data Form, the Beck Anxiety Inventory (BAI), and the Beck Depression Inventory (BDI) were administered to patients, and venous blood samples were taken after blood pressure measurement. S100B and Urotensin-II levels were measured using the Enzyme-Linked Immunosorbent Assay (ELISA) method.[¤]RESULTS[|]The participants' mean BDI score was 10.4+-7.61 and the mean BAI score was 15.6+-9.61. A positive correlation was determined between depression and anxiety scores and systolic blood pressure (p=0.049, r= 0.160; p<0.01, r=0.292). A positive relationship was found between the BAI scores and Urotensin-II levels (p= 0.043, r= 0.164). A positive correlation was also found between Urotensin-II levels and S100B levels (p<0.01, r= 0.711). A statistically significant difference was observed in serum Urotensin-II levels between the high depression scores and low depression scores (p=0.017), but no significant difference was observed in S100B levels.[¤]DISCUSSION AND CONCLUSION[|]It was concluded that the Urotensin-II levels increased in line with anxiety levels in patients with essential hypertension. It was also found that the Urotensin-II levels were higher in hypertensive patients with high scores in BDI. This study is expected to contribute to the future studies that will investigate the role of Urotensin-II and S100B in the etiology of essential hypertension, which is very commonly accompanied by anxiety and depressive symptoms.[¤] |
| first_indexed | 2024-04-10T12:30:49Z |
| format | Article |
| id | doaj.art-5fd61ec428e0404d90436ec1acbcd521 |
| institution | Directory Open Access Journal |
| issn | 1302-0099 |
| language | English |
| last_indexed | 2024-04-10T12:30:49Z |
| publishDate | 2021-09-01 |
| publisher | ANP Publishing |
| record_format | Article |
| series | Klinik Psikiyatri Dergisi |
| spelling | doaj.art-5fd61ec428e0404d90436ec1acbcd5212023-02-15T16:14:57ZengANP PublishingKlinik Psikiyatri Dergisi1302-00992021-09-0124331532310.5505/kpd.2021.67044KPD-67044The relationship between anxiety and serum urotensin-II and S100B levels in patients with essential hypertension (eng)Aslı Kazğan0Sevda Korkmaz1Sevler Yildiz2Hasan Korkmaz3Selda Telo4Murad Atmaca5Siverek State Hospital, Department of Psychiatry, Şanlıurfa, TurkeyFırat University, Medical Faculty, Department of Psychiatry, Elazığ, TurkeyBinali Yıldırım University, Medical Faculty, Department of Psychiatry, Erzincan, TurkeyFırat University, Medical Faculty, Department Of Cardiology, Elazığ, TurkeyFırat University, Medical Faculty, Department Of Biochemistry, Elazığ, TurkeyFırat University, Medical Faculty, Department of Psychiatry, Elazığ, TurkeyINTRODUCTION[|]In hypertensive people, some biochemical parameters that are associated with oxidative stress and endothelial functions may play a role in the manifestation of anxiety symptoms, and even in the intensification of clinical symptoms of the disease. The objective of this correlational study is to examine the association between the severity of anxiety and levels of oxidative stress parameters including Urotensin-II and S100B protein in patients with essential hypertension.[¤]METHODS[|]A total of 153 patients meeting the study criteria who presented to the department of cardiology and received outpatient treatment were included in the study. Sociodemographic and Clinical Data Form, the Beck Anxiety Inventory (BAI), and the Beck Depression Inventory (BDI) were administered to patients, and venous blood samples were taken after blood pressure measurement. S100B and Urotensin-II levels were measured using the Enzyme-Linked Immunosorbent Assay (ELISA) method.[¤]RESULTS[|]The participants' mean BDI score was 10.4+-7.61 and the mean BAI score was 15.6+-9.61. A positive correlation was determined between depression and anxiety scores and systolic blood pressure (p=0.049, r= 0.160; p<0.01, r=0.292). A positive relationship was found between the BAI scores and Urotensin-II levels (p= 0.043, r= 0.164). A positive correlation was also found between Urotensin-II levels and S100B levels (p<0.01, r= 0.711). A statistically significant difference was observed in serum Urotensin-II levels between the high depression scores and low depression scores (p=0.017), but no significant difference was observed in S100B levels.[¤]DISCUSSION AND CONCLUSION[|]It was concluded that the Urotensin-II levels increased in line with anxiety levels in patients with essential hypertension. It was also found that the Urotensin-II levels were higher in hypertensive patients with high scores in BDI. This study is expected to contribute to the future studies that will investigate the role of Urotensin-II and S100B in the etiology of essential hypertension, which is very commonly accompanied by anxiety and depressive symptoms.[¤]https://jag.journalagent.com/z4/download_fulltext.asp?pdir=kpd&un=KPD-67044essential hypertensionanxietyurotensin-iis100b |
| spellingShingle | Aslı Kazğan Sevda Korkmaz Sevler Yildiz Hasan Korkmaz Selda Telo Murad Atmaca The relationship between anxiety and serum urotensin-II and S100B levels in patients with essential hypertension (eng) Klinik Psikiyatri Dergisi essential hypertension anxiety urotensin-ii s100b |
| title | The relationship between anxiety and serum urotensin-II and S100B levels in patients with essential hypertension (eng) |
| title_full | The relationship between anxiety and serum urotensin-II and S100B levels in patients with essential hypertension (eng) |
| title_fullStr | The relationship between anxiety and serum urotensin-II and S100B levels in patients with essential hypertension (eng) |
| title_full_unstemmed | The relationship between anxiety and serum urotensin-II and S100B levels in patients with essential hypertension (eng) |
| title_short | The relationship between anxiety and serum urotensin-II and S100B levels in patients with essential hypertension (eng) |
| title_sort | relationship between anxiety and serum urotensin ii and s100b levels in patients with essential hypertension eng |
| topic | essential hypertension anxiety urotensin-ii s100b |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=kpd&un=KPD-67044 |
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