Cross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease

Cross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease

Effective treatment options for advanced colorectal cancer (CRC) are limited, survival rates are poor and this disease continues to be a leading cause of cancer-related deaths worldwide. Despite being a highly heterogeneous disease, a large subset of individuals with sporadic CRC typically harbor re...

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Bibliographic Details
Main Authors: Peter J. Belmont, Eva Budinska, Ping Jiang, Mark J. Sinnamon, Erin Coffee, Jatin Roper, Tao Xie, Paul A. Rejto, Sahra Derkits, Owen J. Sansom, Mauro Delorenzi, Sabine Tejpar, Kenneth E. Hung, Eric S. Martin
Format: Article
Language:English
Published: The Company of Biologists 2014-06-01
Series:Disease Models & Mechanisms
Subjects:
KRAS
BRAF
MAPK
Colorectal cancer
GEMM
Genomic signatures
Online Access:http://dmm.biologists.org/content/7/6/613

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