A novel strategy to increase the proliferative potential of adult human β-cells while maintaining their differentiated phenotype.

A novel strategy to increase the proliferative potential of adult human β-cells while maintaining their differentiated phenotype.

Our previous studies demonstrated that Wnt/GSK-3/β-catenin and mTOR signaling are necessary to stimulate proliferative processes in adult human β-cells. Direct inhibition of GSK-3, that engages Wnt signaling downstream of the Wnt receptor, increases β-catenin nuclear translocation and β-cell prolife...

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Bibliographic Details
Main Authors: Haytham Aly, Nidhi Rohatgi, Connie A Marshall, Tiffani C Grossenheider, Hiroyuki Miyoshi, Thaddeus S Stappenbeck, Scot J Matkovich, Michael L McDaniel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3680388?pdf=render

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