I-131-Metaiodobenzylguanidine therapy with allogeneic cord blood stem cell transplantation for recurrent neuroblastoma
<p>Abstract</p> <p>Iodine-131-metaiodiobenzylguanidine (<sup>131</sup>I-MIBG) therapy combined with allogeneic cord blood stem cell transplantation (SCT) was used to treat a 4-year-old girl with recurrent neuroblastoma. The patient experienced relapse 2 years after rece...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-10-01
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| Series: | Italian Journal of Pediatrics |
| Subjects: | |
| Online Access: | http://www.ijponline.net/content/38/1/53 |
| Summary: | <p>Abstract</p> <p>Iodine-131-metaiodiobenzylguanidine (<sup>131</sup>I-MIBG) therapy combined with allogeneic cord blood stem cell transplantation (SCT) was used to treat a 4-year-old girl with recurrent neuroblastoma. The patient experienced relapse 2 years after receiving first-line therapies, which included chemotherapy, surgical resection, irradiation, and autologous peripheral SCT. Although <sup>131</sup>I-MIBG treatment did not achieve complete remission, the size of the tumor was reduced after treatment. Based on our findings, we suggest that <sup>131</sup>I-MIBG treatment with myeloablative allogeneic SCT should be considered as first-line therapy for high-risk neuroblastoma patients when possible.</p> |
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| ISSN: | 1720-8424 1824-7288 |