I-131-Metaiodobenzylguanidine therapy with allogeneic cord blood stem cell transplantation for recurrent neuroblastoma
<p>Abstract</p> <p>Iodine-131-metaiodiobenzylguanidine (<sup>131</sup>I-MIBG) therapy combined with allogeneic cord blood stem cell transplantation (SCT) was used to treat a 4-year-old girl with recurrent neuroblastoma. The patient experienced relapse 2 years after rece...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-10-01
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| Series: | Italian Journal of Pediatrics |
| Subjects: | |
| Online Access: | http://www.ijponline.net/content/38/1/53 |
| _version_ | 1811287752151400448 |
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| author | Sato Yuya Kurosawa Hidemitsu Fukushima Keitaro Okuya Mayuko Hagisawa Susumu Sugita Kenichi Arisaka Osamu Inaki Anri Wakabayashi Hiroshi Nakamura Ayane Fukuoka Makoto Kayano Daiki Kinuya Seigo |
| author_facet | Sato Yuya Kurosawa Hidemitsu Fukushima Keitaro Okuya Mayuko Hagisawa Susumu Sugita Kenichi Arisaka Osamu Inaki Anri Wakabayashi Hiroshi Nakamura Ayane Fukuoka Makoto Kayano Daiki Kinuya Seigo |
| author_sort | Sato Yuya |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Iodine-131-metaiodiobenzylguanidine (<sup>131</sup>I-MIBG) therapy combined with allogeneic cord blood stem cell transplantation (SCT) was used to treat a 4-year-old girl with recurrent neuroblastoma. The patient experienced relapse 2 years after receiving first-line therapies, which included chemotherapy, surgical resection, irradiation, and autologous peripheral SCT. Although <sup>131</sup>I-MIBG treatment did not achieve complete remission, the size of the tumor was reduced after treatment. Based on our findings, we suggest that <sup>131</sup>I-MIBG treatment with myeloablative allogeneic SCT should be considered as first-line therapy for high-risk neuroblastoma patients when possible.</p> |
| first_indexed | 2024-04-13T03:23:57Z |
| format | Article |
| id | doaj.art-5fd8f21854ea4517a96974be4739c269 |
| institution | Directory Open Access Journal |
| issn | 1720-8424 1824-7288 |
| language | English |
| last_indexed | 2024-04-13T03:23:57Z |
| publishDate | 2012-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Italian Journal of Pediatrics |
| spelling | doaj.art-5fd8f21854ea4517a96974be4739c2692022-12-22T03:04:42ZengBMCItalian Journal of Pediatrics1720-84241824-72882012-10-013815310.1186/1824-7288-38-53I-131-Metaiodobenzylguanidine therapy with allogeneic cord blood stem cell transplantation for recurrent neuroblastomaSato YuyaKurosawa HidemitsuFukushima KeitaroOkuya MayukoHagisawa SusumuSugita KenichiArisaka OsamuInaki AnriWakabayashi HiroshiNakamura AyaneFukuoka MakotoKayano DaikiKinuya Seigo<p>Abstract</p> <p>Iodine-131-metaiodiobenzylguanidine (<sup>131</sup>I-MIBG) therapy combined with allogeneic cord blood stem cell transplantation (SCT) was used to treat a 4-year-old girl with recurrent neuroblastoma. The patient experienced relapse 2 years after receiving first-line therapies, which included chemotherapy, surgical resection, irradiation, and autologous peripheral SCT. Although <sup>131</sup>I-MIBG treatment did not achieve complete remission, the size of the tumor was reduced after treatment. Based on our findings, we suggest that <sup>131</sup>I-MIBG treatment with myeloablative allogeneic SCT should be considered as first-line therapy for high-risk neuroblastoma patients when possible.</p>http://www.ijponline.net/content/38/1/53MIBGNeuroblastomaAllogeneic cord blood stem cell transplantation |
| spellingShingle | Sato Yuya Kurosawa Hidemitsu Fukushima Keitaro Okuya Mayuko Hagisawa Susumu Sugita Kenichi Arisaka Osamu Inaki Anri Wakabayashi Hiroshi Nakamura Ayane Fukuoka Makoto Kayano Daiki Kinuya Seigo I-131-Metaiodobenzylguanidine therapy with allogeneic cord blood stem cell transplantation for recurrent neuroblastoma Italian Journal of Pediatrics MIBG Neuroblastoma Allogeneic cord blood stem cell transplantation |
| title | I-131-Metaiodobenzylguanidine therapy with allogeneic cord blood stem cell transplantation for recurrent neuroblastoma |
| title_full | I-131-Metaiodobenzylguanidine therapy with allogeneic cord blood stem cell transplantation for recurrent neuroblastoma |
| title_fullStr | I-131-Metaiodobenzylguanidine therapy with allogeneic cord blood stem cell transplantation for recurrent neuroblastoma |
| title_full_unstemmed | I-131-Metaiodobenzylguanidine therapy with allogeneic cord blood stem cell transplantation for recurrent neuroblastoma |
| title_short | I-131-Metaiodobenzylguanidine therapy with allogeneic cord blood stem cell transplantation for recurrent neuroblastoma |
| title_sort | i 131 metaiodobenzylguanidine therapy with allogeneic cord blood stem cell transplantation for recurrent neuroblastoma |
| topic | MIBG Neuroblastoma Allogeneic cord blood stem cell transplantation |
| url | http://www.ijponline.net/content/38/1/53 |
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