Concentrations of Ciprofloxacin in the World’s Rivers Are Associated with the Prevalence of Fluoroquinolone Resistance in <i>Escherichia coli</i>: A Global Ecological Analysis
Background: Extremely low concentrations of ciprofloxacin may select for antimicrobial resistance. A recent global survey found that ciprofloxacin concentrations exceeded safe levels at 64 sites. In this study, I assessed if national median ciprofloxacin concentrations in rivers were associated with...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/3/417 |
| _version_ | 1797473211059798016 |
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| author | Chris Kenyon |
| author_facet | Chris Kenyon |
| author_sort | Chris Kenyon |
| collection | DOAJ |
| description | Background: Extremely low concentrations of ciprofloxacin may select for antimicrobial resistance. A recent global survey found that ciprofloxacin concentrations exceeded safe levels at 64 sites. In this study, I assessed if national median ciprofloxacin concentrations in rivers were associated with fluoroquinolone resistance in <i>Escherichia coli</i>. Methods: Spearman’s regression was used to assess the country-level association between the national prevalence of fluoroquinolone resistance in <i>E. coli</i> and the median ciprofloxacin concentration in the country’s rivers. Results: The prevalence of fluoroquinolone resistance in <i>E. coli</i> was positively correlated with the concentration of ciprofloxacin in rivers (ρ = 0.36; <i>p</i> = 0.011; <i>n</i> = 48). Discussion: Steps to reducing the concentrations of fluoroquinolones in rivers may help prevent the emergence of resistance in <i>E. coli</i> and other bacterial species. |
| first_indexed | 2024-03-09T20:11:37Z |
| format | Article |
| id | doaj.art-5fd9e747d48c4c369b007c55242081c9 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T20:11:37Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-5fd9e747d48c4c369b007c55242081c92023-11-24T00:12:17ZengMDPI AGAntibiotics2079-63822022-03-0111341710.3390/antibiotics11030417Concentrations of Ciprofloxacin in the World’s Rivers Are Associated with the Prevalence of Fluoroquinolone Resistance in <i>Escherichia coli</i>: A Global Ecological AnalysisChris Kenyon0HIV/STI Unit, Institute of Tropical Medicine, Antwerp 2000, BelgiumBackground: Extremely low concentrations of ciprofloxacin may select for antimicrobial resistance. A recent global survey found that ciprofloxacin concentrations exceeded safe levels at 64 sites. In this study, I assessed if national median ciprofloxacin concentrations in rivers were associated with fluoroquinolone resistance in <i>Escherichia coli</i>. Methods: Spearman’s regression was used to assess the country-level association between the national prevalence of fluoroquinolone resistance in <i>E. coli</i> and the median ciprofloxacin concentration in the country’s rivers. Results: The prevalence of fluoroquinolone resistance in <i>E. coli</i> was positively correlated with the concentration of ciprofloxacin in rivers (ρ = 0.36; <i>p</i> = 0.011; <i>n</i> = 48). Discussion: Steps to reducing the concentrations of fluoroquinolones in rivers may help prevent the emergence of resistance in <i>E. coli</i> and other bacterial species.https://www.mdpi.com/2079-6382/11/3/417riversone health<i>E. coli</i>fluoroquinolonesantimicrobial resistanceAMR |
| spellingShingle | Chris Kenyon Concentrations of Ciprofloxacin in the World’s Rivers Are Associated with the Prevalence of Fluoroquinolone Resistance in <i>Escherichia coli</i>: A Global Ecological Analysis Antibiotics rivers one health <i>E. coli</i> fluoroquinolones antimicrobial resistance AMR |
| title | Concentrations of Ciprofloxacin in the World’s Rivers Are Associated with the Prevalence of Fluoroquinolone Resistance in <i>Escherichia coli</i>: A Global Ecological Analysis |
| title_full | Concentrations of Ciprofloxacin in the World’s Rivers Are Associated with the Prevalence of Fluoroquinolone Resistance in <i>Escherichia coli</i>: A Global Ecological Analysis |
| title_fullStr | Concentrations of Ciprofloxacin in the World’s Rivers Are Associated with the Prevalence of Fluoroquinolone Resistance in <i>Escherichia coli</i>: A Global Ecological Analysis |
| title_full_unstemmed | Concentrations of Ciprofloxacin in the World’s Rivers Are Associated with the Prevalence of Fluoroquinolone Resistance in <i>Escherichia coli</i>: A Global Ecological Analysis |
| title_short | Concentrations of Ciprofloxacin in the World’s Rivers Are Associated with the Prevalence of Fluoroquinolone Resistance in <i>Escherichia coli</i>: A Global Ecological Analysis |
| title_sort | concentrations of ciprofloxacin in the world s rivers are associated with the prevalence of fluoroquinolone resistance in i escherichia coli i a global ecological analysis |
| topic | rivers one health <i>E. coli</i> fluoroquinolones antimicrobial resistance AMR |
| url | https://www.mdpi.com/2079-6382/11/3/417 |
| work_keys_str_mv | AT chriskenyon concentrationsofciprofloxacinintheworldsriversareassociatedwiththeprevalenceoffluoroquinoloneresistanceiniescherichiacoliiaglobalecologicalanalysis |